Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder
The purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia, and schizoaffective disorder and alcohol use might aggravate this phenomen...
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Format: | Article |
Language: | English |
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MDPI AG
2021-05-01
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Series: | Brain Sciences |
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Online Access: | https://www.mdpi.com/2076-3425/11/6/688 |
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record_format |
Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Atiqul Haq Mazumder Jennifer Barnett Nina Lindberg Minna Torniainen-Holm Markku Lähteenvuo Kaisla Lahdensuo Martta Kerkelä Jarmo Hietala Erkki Tapio Isometsä Olli Kampman Tuula Kieseppä Tuomas Jukuri Katja Häkkinen Erik Cederlöf Willehard Haaki Risto Kajanne Asko Wegelius Teemu Männynsalo Jussi Niemi-Pynttäri Kimmo Suokas Jouko Lönnqvist Solja Niemelä Jari Tiihonen Tiina Paunio Aarno Palotie Jaana Suvisaari Juha Veijola |
spellingShingle |
Atiqul Haq Mazumder Jennifer Barnett Nina Lindberg Minna Torniainen-Holm Markku Lähteenvuo Kaisla Lahdensuo Martta Kerkelä Jarmo Hietala Erkki Tapio Isometsä Olli Kampman Tuula Kieseppä Tuomas Jukuri Katja Häkkinen Erik Cederlöf Willehard Haaki Risto Kajanne Asko Wegelius Teemu Männynsalo Jussi Niemi-Pynttäri Kimmo Suokas Jouko Lönnqvist Solja Niemelä Jari Tiihonen Tiina Paunio Aarno Palotie Jaana Suvisaari Juha Veijola Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder Brain Sciences cognition visual memory reaction time alcohol schizophrenia schizoaffective disorder |
author_facet |
Atiqul Haq Mazumder Jennifer Barnett Nina Lindberg Minna Torniainen-Holm Markku Lähteenvuo Kaisla Lahdensuo Martta Kerkelä Jarmo Hietala Erkki Tapio Isometsä Olli Kampman Tuula Kieseppä Tuomas Jukuri Katja Häkkinen Erik Cederlöf Willehard Haaki Risto Kajanne Asko Wegelius Teemu Männynsalo Jussi Niemi-Pynttäri Kimmo Suokas Jouko Lönnqvist Solja Niemelä Jari Tiihonen Tiina Paunio Aarno Palotie Jaana Suvisaari Juha Veijola |
author_sort |
Atiqul Haq Mazumder |
title |
Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder |
title_short |
Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder |
title_full |
Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder |
title_fullStr |
Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder |
title_full_unstemmed |
Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective Disorder |
title_sort |
reaction time and visual memory in connection with alcohol use in schizophrenia and schizoaffective disorder |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2021-05-01 |
description |
The purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia, and schizoaffective disorder and alcohol use might aggravate this phenomenon. The study population included 3362 individuals from Finland with diagnoses of schizophrenia or schizoaffective disorder. Hazardous drinking was screened with the AUDIT-C (Alcohol Use Disorders Identification Test for Consumption) screening tool. Alcohol use disorder (AUD) diagnoses were obtained from national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: The Five-Choice Serial Reaction Time Task (5-CSRTT) or the reaction time (RT) test and the Paired Associative Learning (PAL) test. The association between alcohol use and the RT and PAL tests was analyzed with log-linear regression and logistic regression, respectively. After adjustment for age, education, housing status, and the age at which the respondents had their first psychotic episodes, hazardous drinking was associated with a lower median RT in females and less variable RT in males, while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores (TEASs) in females. Our findings of positive associations between alcohol and cognition in schizophrenia and schizoaffective disorder are unique. |
topic |
cognition visual memory reaction time alcohol schizophrenia schizoaffective disorder |
url |
https://www.mdpi.com/2076-3425/11/6/688 |
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doaj-e1b30415062d4ae8bea78082ba2ce9762021-06-01T00:52:56ZengMDPI AGBrain Sciences2076-34252021-05-011168868810.3390/brainsci11060688Reaction Time and Visual Memory in Connection with Alcohol Use in Schizophrenia and Schizoaffective DisorderAtiqul Haq Mazumder0Jennifer Barnett1Nina Lindberg2Minna Torniainen-Holm3Markku Lähteenvuo4Kaisla Lahdensuo5Martta Kerkelä6Jarmo Hietala7Erkki Tapio Isometsä8Olli Kampman9Tuula Kieseppä10Tuomas Jukuri11Katja Häkkinen12Erik Cederlöf13Willehard Haaki14Risto Kajanne15Asko Wegelius16Teemu Männynsalo17Jussi Niemi-Pynttäri18Kimmo Suokas19Jouko Lönnqvist20Solja Niemelä21Jari Tiihonen22Tiina Paunio23Aarno Palotie24Jaana Suvisaari25Juha Veijola26Department of Psychiatry, University of Oulu, 90014 Oulu, FinlandCambridge Cognition, University of Cambridge, Cambridge CB25 9TU, UKDepartment of Psychiatry, Helsinki University Hospital, University of Helsinki, 00029 Helsinki, FinlandMental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, FinlandDepartment of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, 70240 Kuopio, FinlandInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, FinlandDepartment of Psychiatry, University of Oulu, 90014 Oulu, FinlandDepartment of Psychiatry, University of Turku, 20014 Turku, FinlandDepartment of Psychiatry, Helsinki University Hospital, University of Helsinki, 00029 Helsinki, FinlandFaculty of Medicine and Health Technology, Tampere University, 33014 Tampere, FinlandDepartment of Psychiatry, Helsinki University Hospital, University of Helsinki, 00029 Helsinki, FinlandDepartment of Psychiatry, University of Oulu, 90014 Oulu, FinlandDepartment of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, 70240 Kuopio, FinlandMental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, FinlandInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, FinlandInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, FinlandDepartment of Psychiatry, Helsinki University Hospital, University of Helsinki, 00029 Helsinki, FinlandInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, FinlandInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, FinlandInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, FinlandMental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, FinlandDepartment of Psychiatry, University of Turku, 20014 Turku, FinlandDepartment of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, 70240 Kuopio, FinlandDepartment of Psychiatry, Helsinki University Hospital, University of Helsinki, 00029 Helsinki, FinlandInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, FinlandMental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, FinlandDepartment of Psychiatry, University of Oulu, 90014 Oulu, FinlandThe purpose of this study was to explore the association between cognition and hazardous drinking and alcohol use disorder in schizophrenia and schizoaffective disorder. Cognition is more or less compromised in schizophrenia, and schizoaffective disorder and alcohol use might aggravate this phenomenon. The study population included 3362 individuals from Finland with diagnoses of schizophrenia or schizoaffective disorder. Hazardous drinking was screened with the AUDIT-C (Alcohol Use Disorders Identification Test for Consumption) screening tool. Alcohol use disorder (AUD) diagnoses were obtained from national registrar data. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: The Five-Choice Serial Reaction Time Task (5-CSRTT) or the reaction time (RT) test and the Paired Associative Learning (PAL) test. The association between alcohol use and the RT and PAL tests was analyzed with log-linear regression and logistic regression, respectively. After adjustment for age, education, housing status, and the age at which the respondents had their first psychotic episodes, hazardous drinking was associated with a lower median RT in females and less variable RT in males, while AUD was associated with a poorer PAL test performance in terms of the total errors adjusted scores (TEASs) in females. Our findings of positive associations between alcohol and cognition in schizophrenia and schizoaffective disorder are unique.https://www.mdpi.com/2076-3425/11/6/688cognitionvisual memoryreaction timealcoholschizophreniaschizoaffective disorder |