Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy
In recent years, there has been a plethora of attempts to discover biomarkers that are more reliable than α-fetoprotein for the early prediction and prognosis of hepatocellular carcinoma (HCC). Efforts have involved such fields as genomics, transcriptomics, epigenetics, microRNA, exosomes,...
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doaj-e1cc88deaeeb4209b670808cddd200402020-11-25T01:45:17ZengMDPI AGMetabolites2218-19892020-01-011025010.3390/metabo10020050metabo10020050Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and TherapyDiren Beyoğlu0Jeffrey R. Idle1Arthur G. Zupko’s Division of Systems Pharmacology and Pharmacogenomics, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, 75 Dekalb Avenue, Brooklyn, NY 11201, USAArthur G. Zupko’s Division of Systems Pharmacology and Pharmacogenomics, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, 75 Dekalb Avenue, Brooklyn, NY 11201, USAIn recent years, there has been a plethora of attempts to discover biomarkers that are more reliable than α-fetoprotein for the early prediction and prognosis of hepatocellular carcinoma (HCC). Efforts have involved such fields as genomics, transcriptomics, epigenetics, microRNA, exosomes, proteomics, glycoproteomics, and metabolomics. HCC arises against a background of inflammation, steatosis, and cirrhosis, due mainly to hepatic insults caused by alcohol abuse, hepatitis B and C virus infection, adiposity, and diabetes. Metabolomics offers an opportunity, without recourse to liver biopsy, to discover biomarkers for premalignant liver disease, thereby alerting the potential of impending HCC. We have reviewed metabolomic studies in alcoholic liver disease (ALD), cholestasis, fibrosis, cirrhosis, nonalcoholic fatty liver (NAFL), and nonalcoholic steatohepatitis (NASH). Specificity was our major criterion in proposing clinical evaluation of indole-3-lactic acid, phenyllactic acid, <i>N</i>-lauroylglycine, decatrienoate, <i>N</i>-acetyltaurine for ALD, urinary sulfated bile acids for cholestasis, cervonoyl ethanolamide for fibrosis, 16α-hydroxyestrone for cirrhosis, and the pattern of acyl carnitines for NAFL and NASH. These examples derive from a large body of published metabolomic observations in various liver diseases in adults, adolescents, and children, together with animal models. Many other options have been tabulated. Metabolomic biomarkers for premalignant liver disease may help reduce the incidence of HCC.https://www.mdpi.com/2218-1989/10/2/50metabolomicslipidomicsbiomarkerpremalignantalcoholic liver diseasecholestasisfibrosiscirrhosisnaflnash |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Diren Beyoğlu Jeffrey R. Idle |
spellingShingle |
Diren Beyoğlu Jeffrey R. Idle Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy Metabolites metabolomics lipidomics biomarker premalignant alcoholic liver disease cholestasis fibrosis cirrhosis nafl nash |
author_facet |
Diren Beyoğlu Jeffrey R. Idle |
author_sort |
Diren Beyoğlu |
title |
Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy |
title_short |
Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy |
title_full |
Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy |
title_fullStr |
Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy |
title_full_unstemmed |
Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy |
title_sort |
metabolomic and lipidomic biomarkers for premalignant liver disease diagnosis and therapy |
publisher |
MDPI AG |
series |
Metabolites |
issn |
2218-1989 |
publishDate |
2020-01-01 |
description |
In recent years, there has been a plethora of attempts to discover biomarkers that are more reliable than α-fetoprotein for the early prediction and prognosis of hepatocellular carcinoma (HCC). Efforts have involved such fields as genomics, transcriptomics, epigenetics, microRNA, exosomes, proteomics, glycoproteomics, and metabolomics. HCC arises against a background of inflammation, steatosis, and cirrhosis, due mainly to hepatic insults caused by alcohol abuse, hepatitis B and C virus infection, adiposity, and diabetes. Metabolomics offers an opportunity, without recourse to liver biopsy, to discover biomarkers for premalignant liver disease, thereby alerting the potential of impending HCC. We have reviewed metabolomic studies in alcoholic liver disease (ALD), cholestasis, fibrosis, cirrhosis, nonalcoholic fatty liver (NAFL), and nonalcoholic steatohepatitis (NASH). Specificity was our major criterion in proposing clinical evaluation of indole-3-lactic acid, phenyllactic acid, <i>N</i>-lauroylglycine, decatrienoate, <i>N</i>-acetyltaurine for ALD, urinary sulfated bile acids for cholestasis, cervonoyl ethanolamide for fibrosis, 16α-hydroxyestrone for cirrhosis, and the pattern of acyl carnitines for NAFL and NASH. These examples derive from a large body of published metabolomic observations in various liver diseases in adults, adolescents, and children, together with animal models. Many other options have been tabulated. Metabolomic biomarkers for premalignant liver disease may help reduce the incidence of HCC. |
topic |
metabolomics lipidomics biomarker premalignant alcoholic liver disease cholestasis fibrosis cirrhosis nafl nash |
url |
https://www.mdpi.com/2218-1989/10/2/50 |
work_keys_str_mv |
AT direnbeyoglu metabolomicandlipidomicbiomarkersforpremalignantliverdiseasediagnosisandtherapy AT jeffreyridle metabolomicandlipidomicbiomarkersforpremalignantliverdiseasediagnosisandtherapy |
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