Novel Anthranilamide-Based FXa Inhibitors: Drug Design, Synthesis and Biological Evaluation

Novel Anthranilamide-Based FXa Inhibitors: Drug Design, Synthesis and Biological Evaluation

Factor Xa (FXa) plays a significant role in the blood coagulation cascade and it has become a promising target for anticoagulation drugs. Three oral direct FXa inhibitors have been approved by the FDA for treating thrombotic diseases. By structure-activity relationship (SAR) analysis upon these FXa...

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Bibliographic Details
Main Authors:	Wenzhi Wang, Jing Yuan, Xiaoli Fu, Fancui Meng, Shijun Zhang, Weiren Xu, Yongnan Xu, Changjiang Huang
Format:	Article
Language:	English
Published:	MDPI AG 2016-04-01
Series:	Molecules
Subjects:	thrombosis FXa inhibitor anthranilamide-based FXa inhibitors docking simulation
Online Access:	http://www.mdpi.com/1420-3049/21/4/491

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