Impact of Serum Prolactin and Testosterone Levels on the Clinical Parameters of Dry Eye in Pregnant Women
Purpose. To explore the relationship between serum prolactin, testosterone level, and tear film parameters. The potential impact of these hormones on the health of the ocular surface in pregnant women was evaluated. Methods. This was a hospital-based cross-sectional study in which ocular symptoms (O...
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doaj-e1daed2fb1ec49e3bd6140977fc52dbd2020-11-25T03:35:50ZengHindawi LimitedJournal of Ophthalmology2090-004X2090-00582020-01-01202010.1155/2020/14916021491602Impact of Serum Prolactin and Testosterone Levels on the Clinical Parameters of Dry Eye in Pregnant WomenSamuel Kyei0Richard K. Dadzie Ephraim1Stephen Animful2Madison Adanusa3Stephen Karim Ali-Baya4Belinda Akorsah5Mabel Antwiwaa Sekyere6Kofi Asiedu7Department of Optometry and Vision Science, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Medical Laboratory Science, School of Allied Health Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Optometry and Vision Science, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, GhanaDivision of Family Medicine, Directorate of University Health Services, University of Cape Coast, Cape Coast, GhanaDepartment of Medical Laboratory Science, School of Allied Health Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Medical Laboratory Science, School of Allied Health Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Medical Laboratory Science, School of Allied Health Sciences, University of Cape Coast, Cape Coast, GhanaEye Clinic, Cosmopolitan Medical Center, North-Dzorwulu, Accra, GhanaPurpose. To explore the relationship between serum prolactin, testosterone level, and tear film parameters. The potential impact of these hormones on the health of the ocular surface in pregnant women was evaluated. Methods. This was a hospital-based cross-sectional study in which ocular symptoms (Ocular Surface Disease Index (OSDI)), tear function (fluorescein tear breakup time, Schirmer’s test 1), corneal and conjunctival staining, meibomian gland (MG) expressibility, and quality of secretion were measured. Lid margin findings including lid notching, thickness, and lid margin telangiectasia were also recorded. Venous blood was collected and the serum concentrations of prolactin and testosterone were determined using ELISA kits. Correlation and multiple linear regression analyses were used to examine predictors of dry eye symptoms and signs. Results. A total of 160 pregnant women participated in the study and their mean age was 30.1 ± 4.6 years (range 18–42 years). The correlation analysis indicated that testosterone concentration did not significantly correlate with any of the clinical parameters hence it was not included in the linear regression analysis. However, prolactin serum concentration correlated significantly with Schirmer’s test 1. Multiple linear regression was done to predict participants’ Schirmer’s test 1 score based upon their ocular surface staining score (oxford grading scale), meibomian gland expressibility, meibomian secretion quality, and serum concentration of prolactin. Only predictors that significantly correlated with Schirmer’s test 1 in the correlation analysis were included in the linear regression analysis. A significant regression equation was obtained (F (2, 157) = 5.119, p=0.007) with an R square of 0.05. Multiple linear regression analysis revealed that concentration of prolactin (ß coefficient = 0.032, p=0.044) and meibomian gland expressibility scores (ß coefficient = 2.14, p=0.016) were associated with Schirmer’s test 1 scores when adjusted for duration of pregnancy. Conclusion. The study showed that increased serum prolactin levels have a weak but positive impact on Schirmer’s test 1 scores whilst serum testosterone level has no association with the clinical parameters of dry eye in pregnant women.http://dx.doi.org/10.1155/2020/1491602 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Samuel Kyei Richard K. Dadzie Ephraim Stephen Animful Madison Adanusa Stephen Karim Ali-Baya Belinda Akorsah Mabel Antwiwaa Sekyere Kofi Asiedu |
spellingShingle |
Samuel Kyei Richard K. Dadzie Ephraim Stephen Animful Madison Adanusa Stephen Karim Ali-Baya Belinda Akorsah Mabel Antwiwaa Sekyere Kofi Asiedu Impact of Serum Prolactin and Testosterone Levels on the Clinical Parameters of Dry Eye in Pregnant Women Journal of Ophthalmology |
author_facet |
Samuel Kyei Richard K. Dadzie Ephraim Stephen Animful Madison Adanusa Stephen Karim Ali-Baya Belinda Akorsah Mabel Antwiwaa Sekyere Kofi Asiedu |
author_sort |
Samuel Kyei |
title |
Impact of Serum Prolactin and Testosterone Levels on the Clinical Parameters of Dry Eye in Pregnant Women |
title_short |
Impact of Serum Prolactin and Testosterone Levels on the Clinical Parameters of Dry Eye in Pregnant Women |
title_full |
Impact of Serum Prolactin and Testosterone Levels on the Clinical Parameters of Dry Eye in Pregnant Women |
title_fullStr |
Impact of Serum Prolactin and Testosterone Levels on the Clinical Parameters of Dry Eye in Pregnant Women |
title_full_unstemmed |
Impact of Serum Prolactin and Testosterone Levels on the Clinical Parameters of Dry Eye in Pregnant Women |
title_sort |
impact of serum prolactin and testosterone levels on the clinical parameters of dry eye in pregnant women |
publisher |
Hindawi Limited |
series |
Journal of Ophthalmology |
issn |
2090-004X 2090-0058 |
publishDate |
2020-01-01 |
description |
Purpose. To explore the relationship between serum prolactin, testosterone level, and tear film parameters. The potential impact of these hormones on the health of the ocular surface in pregnant women was evaluated. Methods. This was a hospital-based cross-sectional study in which ocular symptoms (Ocular Surface Disease Index (OSDI)), tear function (fluorescein tear breakup time, Schirmer’s test 1), corneal and conjunctival staining, meibomian gland (MG) expressibility, and quality of secretion were measured. Lid margin findings including lid notching, thickness, and lid margin telangiectasia were also recorded. Venous blood was collected and the serum concentrations of prolactin and testosterone were determined using ELISA kits. Correlation and multiple linear regression analyses were used to examine predictors of dry eye symptoms and signs. Results. A total of 160 pregnant women participated in the study and their mean age was 30.1 ± 4.6 years (range 18–42 years). The correlation analysis indicated that testosterone concentration did not significantly correlate with any of the clinical parameters hence it was not included in the linear regression analysis. However, prolactin serum concentration correlated significantly with Schirmer’s test 1. Multiple linear regression was done to predict participants’ Schirmer’s test 1 score based upon their ocular surface staining score (oxford grading scale), meibomian gland expressibility, meibomian secretion quality, and serum concentration of prolactin. Only predictors that significantly correlated with Schirmer’s test 1 in the correlation analysis were included in the linear regression analysis. A significant regression equation was obtained (F (2, 157) = 5.119, p=0.007) with an R square of 0.05. Multiple linear regression analysis revealed that concentration of prolactin (ß coefficient = 0.032, p=0.044) and meibomian gland expressibility scores (ß coefficient = 2.14, p=0.016) were associated with Schirmer’s test 1 scores when adjusted for duration of pregnancy. Conclusion. The study showed that increased serum prolactin levels have a weak but positive impact on Schirmer’s test 1 scores whilst serum testosterone level has no association with the clinical parameters of dry eye in pregnant women. |
url |
http://dx.doi.org/10.1155/2020/1491602 |
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