miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis

miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis

MicroRNA-29a (miR-29a) has been shown to ameliorate hepatocellular damage, such as in the context of non-alcoholic fatty liver disease (NAFLD), steatohepatitis (NASH), and cholestatic injury. However, the mechanism mediating the hepatoprotective effect of miR-29a in diet-induced NASH remains elusive...

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Bibliographic Details
Main Authors: Ya-Ling Yang, Pei-Wen Wang, Feng-Sheng Wang, Hung-Yu Lin, Ying-Hsien Huang
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
microRNA-29a
NASH
liver fibrosis
GSK3β
SIRT1
proteostatic stress
Online Access:https://www.mdpi.com/1422-0067/21/18/6884

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