Abnormal Fixational Eye Movements in Amblyopia.
PURPOSE:Fixational saccades shift the foveal image to counteract visual fading related to neural adaptation. Drifts are slow eye movements between two adjacent fixational saccades. We quantified fixational saccades and asked whether their changes could be attributed to pathologic drifts seen in ambl...
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doaj-e1edc2224ac544b39d56dd29e0aa76732020-11-25T02:00:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01113e014995310.1371/journal.pone.0149953Abnormal Fixational Eye Movements in Amblyopia.Aasef G ShaikhJorge Otero-MillanPriyanka KumarFatema F GhasiaPURPOSE:Fixational saccades shift the foveal image to counteract visual fading related to neural adaptation. Drifts are slow eye movements between two adjacent fixational saccades. We quantified fixational saccades and asked whether their changes could be attributed to pathologic drifts seen in amblyopia, one of the most common causes of blindness in childhood. METHODS:Thirty-six pediatric subjects with varying severity of amblyopia and eleven healthy age-matched controls held their gaze on a visual target. Eye movements were measured with high-resolution video-oculography during fellow eye-viewing and amblyopic eye-viewing conditions. Fixational saccades and drifts were analyzed in the amblyopic and fellow eye and compared with controls. RESULTS:We found an increase in the amplitude with decreased frequency of fixational saccades in children with amblyopia. These alterations in fixational eye movements correlated with the severity of their amblyopia. There was also an increase in eye position variance during drifts in amblyopes. There was no correlation between the eye position variance or the eye velocity during ocular drifts and the amplitude of subsequent fixational saccade. Our findings suggest that abnormalities in fixational saccades in amblyopia are independent of the ocular drift. DISCUSSION:This investigation of amblyopia in pediatric age group quantitatively characterizes the fixation instability. Impaired properties of fixational saccades could be the consequence of abnormal processing and reorganization of the visual system in amblyopia. Paucity in the visual feedback during amblyopic eye-viewing condition can attribute to the increased eye position variance and drift velocity.http://europepmc.org/articles/PMC4773232?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aasef G Shaikh Jorge Otero-Millan Priyanka Kumar Fatema F Ghasia |
spellingShingle |
Aasef G Shaikh Jorge Otero-Millan Priyanka Kumar Fatema F Ghasia Abnormal Fixational Eye Movements in Amblyopia. PLoS ONE |
author_facet |
Aasef G Shaikh Jorge Otero-Millan Priyanka Kumar Fatema F Ghasia |
author_sort |
Aasef G Shaikh |
title |
Abnormal Fixational Eye Movements in Amblyopia. |
title_short |
Abnormal Fixational Eye Movements in Amblyopia. |
title_full |
Abnormal Fixational Eye Movements in Amblyopia. |
title_fullStr |
Abnormal Fixational Eye Movements in Amblyopia. |
title_full_unstemmed |
Abnormal Fixational Eye Movements in Amblyopia. |
title_sort |
abnormal fixational eye movements in amblyopia. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
PURPOSE:Fixational saccades shift the foveal image to counteract visual fading related to neural adaptation. Drifts are slow eye movements between two adjacent fixational saccades. We quantified fixational saccades and asked whether their changes could be attributed to pathologic drifts seen in amblyopia, one of the most common causes of blindness in childhood. METHODS:Thirty-six pediatric subjects with varying severity of amblyopia and eleven healthy age-matched controls held their gaze on a visual target. Eye movements were measured with high-resolution video-oculography during fellow eye-viewing and amblyopic eye-viewing conditions. Fixational saccades and drifts were analyzed in the amblyopic and fellow eye and compared with controls. RESULTS:We found an increase in the amplitude with decreased frequency of fixational saccades in children with amblyopia. These alterations in fixational eye movements correlated with the severity of their amblyopia. There was also an increase in eye position variance during drifts in amblyopes. There was no correlation between the eye position variance or the eye velocity during ocular drifts and the amplitude of subsequent fixational saccade. Our findings suggest that abnormalities in fixational saccades in amblyopia are independent of the ocular drift. DISCUSSION:This investigation of amblyopia in pediatric age group quantitatively characterizes the fixation instability. Impaired properties of fixational saccades could be the consequence of abnormal processing and reorganization of the visual system in amblyopia. Paucity in the visual feedback during amblyopic eye-viewing condition can attribute to the increased eye position variance and drift velocity. |
url |
http://europepmc.org/articles/PMC4773232?pdf=render |
work_keys_str_mv |
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