Oligodendroglial tumours: subventricular zone involvement and seizure history are associated with CIC mutation status

• Main Authors: Zhenyin Liu, Hongsheng Liu, Zhenqing Liu, Jing Zhang
• Format: Article
• Language: English
• Published: BMC 2019-06-01
• Series: BMC Neurology
• Subjects: Oligodendroglial Tumours; CIC mutation; Subventricular zone involvement; Logistic regression; Seizure history
• Online Access: http://link.springer.com/article/10.1186/s12883-019-1362-y

Abstract Background CIC-mutant oligodendroglial tumours linked to better prognosis. We aim to investigate associations between CIC gene mutation status, MR characteristics and clinical features. Methods Imaging and genomic data from the Cancer Genome Atlas and the Cancer Imaging Archive (TCGA/TCIA) for 59 patients with oligodendroglial tumours were used. Differences between CIC mutation and CIC wild-type were tested using Chi-square test and binary logistic regression analysis. Results In univariate analysis, the clinical variables and MR features, which consisted 3 selected features (subventricular zone[SVZ] involvement, volume and seizure history) were associated with CIC mutation status (all p < 0.05). A multivariate logistic regression analysis identified that seizure history (no vs. yes odd ratio [OR]: 28.960, 95 confidence interval [CI]:2.625–319.49, p = 0.006) and SVZ involvement (SVZ- vs. SVZ+ OR: 77.092, p = 0.003; 95% CI: 4.578–1298.334) were associated with a higher incidence of CIC mutation status. The nomogram showed good discrimination, with a C-index of 0.906 (95% CI: 0.812–1.000) and was well calibrated. SVZ- group has increased (SVZ- vs. SVZ+, hazard ratio [HR]: 4.500, p = 0.04; 95% CI: 1.069–18.945) overall survival. Conclusions Absence of seizure history and SVZ involvement (−) was associated with a higher incidence of CIC mutation.