Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy.

Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy.

The characteristic neuropathological changes associated with Alzheimer's disease (AD) and other lines of evidence support the amyloid cascade hypothesis. Viewing amyloid deposits as the prime instigator of dementia has now led to clinical trials of multiple strategies to remove or prevent their...

Full description

Bibliographic Details
Main Authors:	Alex E Roher, David H Cribbs, Ronald C Kim, Chera L Maarouf, Charisse M Whiteside, Tyler A Kokjohn, Ian D Daugs, Elizabeth Head, Carolyn Liebsack, Geidy Serrano, Christine Belden, Marwan N Sabbagh, Thomas G Beach
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3605408?pdf=render

Similar Items

The biochemical aftermath of anti-amyloid immunotherapy
by: Nicoll James AR, et al.
Published: (2010-10-01)

Senescence as an Amyloid Cascade: The Amyloid Senescence Hypothesis
by: Chaska C. Walton, et al.
Published: (2020-05-01)

Amyloid Cascade Hypothesis Perspective on Alzheimer's Disease

Impaired hepatic amyloid-beta degradation in Alzheimer's disease.
by: Chera L Maarouf, et al.
Published: (2018-01-01)

Alzheimer's Disease and the Amyloid Cascade Hypothesis: A Critical Review
by: Christiane Reitz
Published: (2012-01-01)

The Pathogenesis of Alzheimer's Disease: A Reevaluation of the “Amyloid Cascade Hypothesis”
by: R. A. Armstrong
Published: (2011-01-01)

Roles for Small G Protein Rac1 in Amyloid Cascade Hypothesis
by: Wang, PiLin
Published: (2010)

Morphological and pathological evolution of the brain microcirculation in aging and Alzheimer's disease.
by: Jesse M Hunter, et al.
Published: (2012-01-01)

Advances in the pathogenesis of Alzheimer’s disease: a re-evaluation of amyloid cascade hypothesis
by: Dong Suzhen, et al.
Published: (2012-09-01)

Amyloid Imaging in Aging and Dementia: Testing the Amyloid Hypothesis In Vivo
by: G. D. Rabinovici, et al.
Published: (2009-01-01)

Biochemical assessment of precuneus and posterior cingulate gyrus in the context of brain aging and Alzheimer's disease.
by: Chera L Maarouf, et al.
Published: (2014-01-01)

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease
by: Fuyuki Kametani, et al.
Published: (2018-01-01)

Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer’s Disease?
by: Tamas Fulop, et al.
Published: (2018-07-01)

Revisiting the Amyloid Cascade Hypothesis: From Anti-Aβ Therapeutics to Auspicious New Ways for Alzheimer’s Disease
by: Md. Sahab Uddin, et al.
Published: (2020-08-01)

Down's Syndrome with Alzheimer's Disease-Like Pathology: What Can It Teach Us about the Amyloid Cascade Hypothesis?
by: Rania M. Bakkar, et al.
Published: (2010-01-01)

Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging.
by: Chera L Maarouf, et al.
Published: (2011-01-01)

Amyloid hypothesis through the lens of Aβ supersaturation
by: Zhefeng Guo
Published: (2021-01-01)

The Beta Amyloid Dysfunction (BAD) Hypothesis for Alzheimer’s Disease
by: Heinz Hillen
Published: (2019-11-01)

Alzheimer’s disease: the Amyloid hypothesis and the Inverse Warburg effect
by: Lloyd eDemetrius, et al.
Published: (2015-01-01)

Bapineuzumab for mild to moderate Alzheimer’s disease: a meta-analysis of randomized controlled trials
by: Abdelrahman Ibrahim Abushouk, et al.
Published: (2017-04-01)

Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau
by: Niklas Mattsson‐Carlgren, et al.
Published: (2021-06-01)

Amyloid accumulation in Down syndrome measured with amyloid load
by: Matthew D. Zammit, et al.
Published: (2020-01-01)

Apolipoprotein E: Essential Catalyst of the Alzheimer Amyloid Cascade
by: Huntington Potter, et al.
Published: (2012-01-01)

The Amyloid Precursor Protein Intracellular Domain-Fe65 Multiprotein Complexes: A Challenge to the Amyloid Hypothesis for Alzheimer's Disease?
by: Daniel A. Bórquez, et al.
Published: (2012-01-01)

Time between milestone events in the Alzheimer's disease amyloid cascade
by: Philip S. Insel, et al.
Published: (2021-02-01)

Immununochemical markers of the amyloid cascade in the hippocampus in motor neuron diseases
by: Ulises Gomez-Pinedo, et al.
Published: (2016-11-01)

Haplotype analysis of candidate genes in the amyloid cascade of Alzheimer's disease
by: Belbin, Olivia
Published: (2007)

he amyloid hypothesis of Alzheimer's disease: past and present, hopes and disappointments
by: I. V. Litvinenko, et al.
Published: (2019-11-01)

The Contribution of the Amyloid Hypothesis to the Understanding of Alzheimer's Disease: A Critical Overview
by: Laura Morelli, et al.
Published: (2012-01-01)

Aducanumab produced a clinically meaningful benefit in association with amyloid lowering
by: Jeffrey Cummings, et al.
Published: (2021-05-01)

Lead discovery of a guanidinyl tryptophan derivative on amyloid cascade inhibition
by: Suwanttananuruk Piyapan, et al.
Published: (2020-06-01)

The amyloid precursor protein: beyond amyloid
by: Zheng Hui, et al.
Published: (2006-07-01)

Amyloid Cardiomyopathy: All that Sparkles is Amyloid
by: Abhinav Saxena, et al.
Published: (2016-01-01)

Reduced clinical and postmortem measures of cardiac pathology in subjects with advanced Alzheimer's Disease
by: Sue Lucia I, et al.
Published: (2011-01-01)

Functional Mammalian Amyloids and Amyloid-Like Proteins
by: Maria S. Rubel, et al.
Published: (2020-08-01)

Amyloid recognition by serum amyloid P component
by: Purvis, Alan Phil
Published: (2002)

Good Amyloid, Bad Amyloid-What's the Difference?
by: Roland G Roberts
Published: (2016-01-01)

Impact of cerebrospinal fluid shunting for idiopathic normal pressure hydrocephalus on the amyloid cascade.
by: Masao Moriya, et al.
Published: (2015-01-01)

Reduced CSF Water Influx in Alzheimer's Disease Supporting the β-Amyloid Clearance Hypothesis.
by: Yuji Suzuki, et al.
Published: (2015-01-01)

Quantitative Appraisal of Ventricular Cerebrospinal Fluid Biomarkers in Neuropathologically Diagnosed Parkinson's Disease Cases Lacking Alzheimer's Disease Pathology
by: Chera L. Maarouf, et al.
Published: (2013-01-01)