Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study
Purpose: MRI has become an essential tool for prion disease diagnosis. However there exist only a few serial MRI studies of prion patients, and these mostly used whole brain summary measures or region of interest based approaches. We present here the first longitudinal voxel-based morphometry (VBM)...
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Elsevier
2017-01-01
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Series: | NeuroImage: Clinical |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158216302029 |
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doaj-e2007be9ba7f44078a6f0132f19ea11f |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Enrico De Vita Gerard R Ridgway Mark J White Marie-Claire Porter Diana Caine Peter Rudge John Collinge Tarek A Yousry Hans Rolf Jager Simon Mead John S Thornton Harpreet Hyare |
spellingShingle |
Enrico De Vita Gerard R Ridgway Mark J White Marie-Claire Porter Diana Caine Peter Rudge John Collinge Tarek A Yousry Hans Rolf Jager Simon Mead John S Thornton Harpreet Hyare Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study NeuroImage: Clinical Prion disease Structural MRI Longitudinal voxel based morphometry 3T MRI CJD |
author_facet |
Enrico De Vita Gerard R Ridgway Mark J White Marie-Claire Porter Diana Caine Peter Rudge John Collinge Tarek A Yousry Hans Rolf Jager Simon Mead John S Thornton Harpreet Hyare |
author_sort |
Enrico De Vita |
title |
Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study |
title_short |
Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study |
title_full |
Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study |
title_fullStr |
Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study |
title_full_unstemmed |
Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study |
title_sort |
neuroanatomical correlates of prion disease progression - a 3t longitudinal voxel-based morphometry study |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2017-01-01 |
description |
Purpose: MRI has become an essential tool for prion disease diagnosis. However there exist only a few serial MRI studies of prion patients, and these mostly used whole brain summary measures or region of interest based approaches. We present here the first longitudinal voxel-based morphometry (VBM) study in prion disease. The aim of this study was to systematically characterise progressive atrophy in patients with prion disease and identify whether atrophy in specific brain structures correlates with clinical assessment.
Methods: Twenty-four prion disease patients with early stage disease (3 sporadic, 2 iatrogenic, 1 variant and 18 inherited CJD) and 25 controls were examined at 3T with a T1-weighted 3D MPRAGE sequence at multiple time-points (2–6 examinations per subject, interval range 0.1–3.2 years). Longitudinal VBM provided intra-subject and inter-subject image alignment, allowing voxel-wise comparison of progressive structural change. Clinical disease progression was assessed using the MRC Prion Disease Rating Scale. Firstly, in patients, we determined the brain regions where grey and white matter volume change between baseline and final examination correlated with the corresponding change in MRC Scale score. Secondly, in the 21/24 patients with interscan interval longer than 3 months, we identified regions where annualised rates of regional volume change in patients were different from rates in age-matched controls. Given the heterogeneity of the cohort, the regions identified reflect the common features of the different prion sub-types studied.
Results: In the patients there were multiple regions where volume loss significantly correlated with decreased MRC scale, partially overlapping with anatomical regions where yearly rates of volume loss were significantly greater than controls. The key anatomical areas involved included: the basal ganglia and thalamus, pons and medulla, the hippocampal formation and the superior parietal lobules. There were no areas demonstrating volume loss significantly higher in controls than patients or negative correlation between volume and MRC Scale score.
Conclusions: Using 3T MRI and longitudinal VBM we have identified key anatomical regions of progressive volume loss which correlate with an established clinical disease severity index and are relevant to clinical deterioration. Localisation of the regions of progressive brain atrophy correlating most strongly with clinical decline may help to provide more targeted imaging endpoints for future clinical trials. |
topic |
Prion disease Structural MRI Longitudinal voxel based morphometry 3T MRI CJD |
url |
http://www.sciencedirect.com/science/article/pii/S2213158216302029 |
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doaj-e2007be9ba7f44078a6f0132f19ea11f2020-11-24T22:42:48ZengElsevierNeuroImage: Clinical2213-15822017-01-0113C899610.1016/j.nicl.2016.10.021Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry studyEnrico De Vita0Gerard R Ridgway1Mark J White2Marie-Claire Porter3Diana Caine4Peter Rudge5John Collinge6Tarek A Yousry7Hans Rolf Jager8Simon Mead9John S Thornton10Harpreet Hyare11Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH Hospitals NHS Foundation Trust, Box 65, Queen Square, London WC1N 3BG, United KingdomWellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, 12 Queen Square, London WC1N 3BG, United KingdomLysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH Hospitals NHS Foundation Trust, Box 65, Queen Square, London WC1N 3BG, United KingdomNational Prion Clinic, National Hospital for Neurology and Neurosurgery, UCLH Hospitals NHS Foundation Trust, Box 98, Queen Square, London WC1N 3BG, United KingdomNational Prion Clinic, National Hospital for Neurology and Neurosurgery, UCLH Hospitals NHS Foundation Trust, Box 98, Queen Square, London WC1N 3BG, United KingdomNational Prion Clinic, National Hospital for Neurology and Neurosurgery, UCLH Hospitals NHS Foundation Trust, Box 98, Queen Square, London WC1N 3BG, United KingdomNational Prion Clinic, National Hospital for Neurology and Neurosurgery, UCLH Hospitals NHS Foundation Trust, Box 98, Queen Square, London WC1N 3BG, United KingdomLysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH Hospitals NHS Foundation Trust, Box 65, Queen Square, London WC1N 3BG, United KingdomLysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH Hospitals NHS Foundation Trust, Box 65, Queen Square, London WC1N 3BG, United KingdomNational Prion Clinic, National Hospital for Neurology and Neurosurgery, UCLH Hospitals NHS Foundation Trust, Box 98, Queen Square, London WC1N 3BG, United KingdomLysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH Hospitals NHS Foundation Trust, Box 65, Queen Square, London WC1N 3BG, United KingdomNational Prion Clinic, National Hospital for Neurology and Neurosurgery, UCLH Hospitals NHS Foundation Trust, Box 98, Queen Square, London WC1N 3BG, United KingdomPurpose: MRI has become an essential tool for prion disease diagnosis. However there exist only a few serial MRI studies of prion patients, and these mostly used whole brain summary measures or region of interest based approaches. We present here the first longitudinal voxel-based morphometry (VBM) study in prion disease. The aim of this study was to systematically characterise progressive atrophy in patients with prion disease and identify whether atrophy in specific brain structures correlates with clinical assessment. Methods: Twenty-four prion disease patients with early stage disease (3 sporadic, 2 iatrogenic, 1 variant and 18 inherited CJD) and 25 controls were examined at 3T with a T1-weighted 3D MPRAGE sequence at multiple time-points (2–6 examinations per subject, interval range 0.1–3.2 years). Longitudinal VBM provided intra-subject and inter-subject image alignment, allowing voxel-wise comparison of progressive structural change. Clinical disease progression was assessed using the MRC Prion Disease Rating Scale. Firstly, in patients, we determined the brain regions where grey and white matter volume change between baseline and final examination correlated with the corresponding change in MRC Scale score. Secondly, in the 21/24 patients with interscan interval longer than 3 months, we identified regions where annualised rates of regional volume change in patients were different from rates in age-matched controls. Given the heterogeneity of the cohort, the regions identified reflect the common features of the different prion sub-types studied. Results: In the patients there were multiple regions where volume loss significantly correlated with decreased MRC scale, partially overlapping with anatomical regions where yearly rates of volume loss were significantly greater than controls. The key anatomical areas involved included: the basal ganglia and thalamus, pons and medulla, the hippocampal formation and the superior parietal lobules. There were no areas demonstrating volume loss significantly higher in controls than patients or negative correlation between volume and MRC Scale score. Conclusions: Using 3T MRI and longitudinal VBM we have identified key anatomical regions of progressive volume loss which correlate with an established clinical disease severity index and are relevant to clinical deterioration. Localisation of the regions of progressive brain atrophy correlating most strongly with clinical decline may help to provide more targeted imaging endpoints for future clinical trials.http://www.sciencedirect.com/science/article/pii/S2213158216302029Prion diseaseStructural MRILongitudinal voxel based morphometry3T MRICJD |