F2C2: a fast tool for the computation of flux coupling in genome-scale metabolic networks
<p>Abstract</p> <p>Background</p> <p>Flux coupling analysis (FCA) has become a useful tool in the constraint-based analysis of genome-scale metabolic networks. FCA allows detecting dependencies between reaction fluxes of metabolic networks at steady-state. On the one ha...
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doaj-e200f910a4c64aa5b59faba667a9b6332020-11-25T00:11:41ZengBMCBMC Bioinformatics1471-21052012-04-011315710.1186/1471-2105-13-57F2C2: a fast tool for the computation of flux coupling in genome-scale metabolic networksLarhlimi AbdelhalimDavid LaszloSelbig JoachimBockmayr Alexander<p>Abstract</p> <p>Background</p> <p>Flux coupling analysis (FCA) has become a useful tool in the constraint-based analysis of genome-scale metabolic networks. FCA allows detecting dependencies between reaction fluxes of metabolic networks at steady-state. On the one hand, this can help in the curation of reconstructed metabolic networks by verifying whether the coupling between reactions is in agreement with the experimental findings. On the other hand, FCA can aid in defining intervention strategies to knock out target reactions.</p> <p>Results</p> <p>We present a new method F2C2 for FCA, which is orders of magnitude faster than previous approaches. As a consequence, FCA of genome-scale metabolic networks can now be performed in a routine manner.</p> <p>Conclusions</p> <p>We propose F2C2 as a fast tool for the computation of flux coupling in genome-scale metabolic networks. F2C2 is freely available for non-commercial use at <url>https://sourceforge.net/projects/f2c2/files/</url>.</p> http://www.biomedcentral.com/1471-2105/13/57 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Larhlimi Abdelhalim David Laszlo Selbig Joachim Bockmayr Alexander |
spellingShingle |
Larhlimi Abdelhalim David Laszlo Selbig Joachim Bockmayr Alexander F2C2: a fast tool for the computation of flux coupling in genome-scale metabolic networks BMC Bioinformatics |
author_facet |
Larhlimi Abdelhalim David Laszlo Selbig Joachim Bockmayr Alexander |
author_sort |
Larhlimi Abdelhalim |
title |
F2C2: a fast tool for the computation of flux coupling in genome-scale metabolic networks |
title_short |
F2C2: a fast tool for the computation of flux coupling in genome-scale metabolic networks |
title_full |
F2C2: a fast tool for the computation of flux coupling in genome-scale metabolic networks |
title_fullStr |
F2C2: a fast tool for the computation of flux coupling in genome-scale metabolic networks |
title_full_unstemmed |
F2C2: a fast tool for the computation of flux coupling in genome-scale metabolic networks |
title_sort |
f2c2: a fast tool for the computation of flux coupling in genome-scale metabolic networks |
publisher |
BMC |
series |
BMC Bioinformatics |
issn |
1471-2105 |
publishDate |
2012-04-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Flux coupling analysis (FCA) has become a useful tool in the constraint-based analysis of genome-scale metabolic networks. FCA allows detecting dependencies between reaction fluxes of metabolic networks at steady-state. On the one hand, this can help in the curation of reconstructed metabolic networks by verifying whether the coupling between reactions is in agreement with the experimental findings. On the other hand, FCA can aid in defining intervention strategies to knock out target reactions.</p> <p>Results</p> <p>We present a new method F2C2 for FCA, which is orders of magnitude faster than previous approaches. As a consequence, FCA of genome-scale metabolic networks can now be performed in a routine manner.</p> <p>Conclusions</p> <p>We propose F2C2 as a fast tool for the computation of flux coupling in genome-scale metabolic networks. F2C2 is freely available for non-commercial use at <url>https://sourceforge.net/projects/f2c2/files/</url>.</p> |
url |
http://www.biomedcentral.com/1471-2105/13/57 |
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