Modulation of Limbic and Prefrontal Connectivity by Electroconvulsive Therapy in Treatment-resistant Depression: A Preliminary Study
Background: Although current models of depression suggest that a sequential modulation of limbic and prefrontal connectivity is needed for illness recovery, neuroimaging studies of electroconvulsive therapy (ECT) have focused on assessing functional connectivity (FC) before and after an ECT course,...
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Format: | Article |
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Elsevier
2016-01-01
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Series: | Brain Stimulation |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1935861X15011171 |
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doaj-e204cb7fb6ea4e3687bc7ddec0a7e088 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marta Cano Narcís Cardoner Mikel Urretavizcaya Ignacio Martínez-Zalacaín Ximena Goldberg Esther Via Oren Contreras-Rodríguez Joan Camprodon Aida de Arriba-Arnau Rosa Hernández-Ribas Jesús Pujol Carles Soriano-Mas José M. Menchón |
spellingShingle |
Marta Cano Narcís Cardoner Mikel Urretavizcaya Ignacio Martínez-Zalacaín Ximena Goldberg Esther Via Oren Contreras-Rodríguez Joan Camprodon Aida de Arriba-Arnau Rosa Hernández-Ribas Jesús Pujol Carles Soriano-Mas José M. Menchón Modulation of Limbic and Prefrontal Connectivity by Electroconvulsive Therapy in Treatment-resistant Depression: A Preliminary Study Brain Stimulation Electroconvulsive therapy Treatment-resistant depression Intralimbic modulation Limbic–prefrontal modulation Treatment early biomarkers |
author_facet |
Marta Cano Narcís Cardoner Mikel Urretavizcaya Ignacio Martínez-Zalacaín Ximena Goldberg Esther Via Oren Contreras-Rodríguez Joan Camprodon Aida de Arriba-Arnau Rosa Hernández-Ribas Jesús Pujol Carles Soriano-Mas José M. Menchón |
author_sort |
Marta Cano |
title |
Modulation of Limbic and Prefrontal Connectivity by Electroconvulsive Therapy in Treatment-resistant Depression: A Preliminary Study |
title_short |
Modulation of Limbic and Prefrontal Connectivity by Electroconvulsive Therapy in Treatment-resistant Depression: A Preliminary Study |
title_full |
Modulation of Limbic and Prefrontal Connectivity by Electroconvulsive Therapy in Treatment-resistant Depression: A Preliminary Study |
title_fullStr |
Modulation of Limbic and Prefrontal Connectivity by Electroconvulsive Therapy in Treatment-resistant Depression: A Preliminary Study |
title_full_unstemmed |
Modulation of Limbic and Prefrontal Connectivity by Electroconvulsive Therapy in Treatment-resistant Depression: A Preliminary Study |
title_sort |
modulation of limbic and prefrontal connectivity by electroconvulsive therapy in treatment-resistant depression: a preliminary study |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2016-01-01 |
description |
Background: Although current models of depression suggest that a sequential modulation of limbic and prefrontal connectivity is needed for illness recovery, neuroimaging studies of electroconvulsive therapy (ECT) have focused on assessing functional connectivity (FC) before and after an ECT course, without characterizing functional changes occurring at early treatment phases. Objective: To assess sequential changes in limbic and prefrontal FC during the course of ECT and their impact on clinical response. Methods: Longitudinal intralimbic and limbic–prefrontal networks connectivity study. We assessed 15 patients with treatment-resistant depression at four different time-points throughout the entire course of an ECT protocol and 10 healthy participants at two functional neuroimaging examinations. Furthermore, a path analysis to test direct and indirect predictive effects of limbic and prefrontal FC changes on clinical response measured with the Hamilton Rating Scale for Depression was also performed. Results: An early significant intralimbic FC decrease significantly predicted a later increase in limbic–prefrontal FC, which in turn significantly predicted clinical improvement at the end of an ECT course. Conclusions: Our data support that treatment response involves sequential changes in FC within regions of the intralimbic and limbic–prefrontal networks. This approach may help in identifying potential early biomarkers of treatment response. |
topic |
Electroconvulsive therapy Treatment-resistant depression Intralimbic modulation Limbic–prefrontal modulation Treatment early biomarkers |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X15011171 |
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doaj-e204cb7fb6ea4e3687bc7ddec0a7e0882021-03-18T04:41:42ZengElsevierBrain Stimulation1935-861X2016-01-01916571Modulation of Limbic and Prefrontal Connectivity by Electroconvulsive Therapy in Treatment-resistant Depression: A Preliminary StudyMarta Cano0Narcís Cardoner1Mikel Urretavizcaya2Ignacio Martínez-Zalacaín3Ximena Goldberg4Esther Via5Oren Contreras-Rodríguez6Joan Camprodon7Aida de Arriba-Arnau8Rosa Hernández-Ribas9Jesús Pujol10Carles Soriano-Mas11José M. Menchón12Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, SpainDepartment of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain; Carlos III Health Institute, CIBERSAM, Spain; Mental Health Department, Parc Taulí Sabadell, Universitat Autònoma de Barcelona, Barcelona, Spain; Corresponding author. Tel.: +0034937231010 ext: 22150; fax: +0034937237181.Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain; Carlos III Health Institute, CIBERSAM, SpainDepartment of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, SpainDepartment of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Carlos III Health Institute, CIBERSAM, SpainDepartment of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, SpainDepartment of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Carlos III Health Institute, CIBERSAM, SpainDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USADepartment of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, SpainDepartment of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain; Carlos III Health Institute, CIBERSAM, SpainCarlos III Health Institute, CIBERSAM, Spain; MRI Research Unit, Hospital del Mar, Barcelona, SpainDepartment of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Carlos III Health Institute, CIBERSAM, Spain; Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona, Barcelona, Spain; Corresponding author. Tel.: +0034932607500 ext: 2864; fax: +0034932607658.Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain; Carlos III Health Institute, CIBERSAM, SpainBackground: Although current models of depression suggest that a sequential modulation of limbic and prefrontal connectivity is needed for illness recovery, neuroimaging studies of electroconvulsive therapy (ECT) have focused on assessing functional connectivity (FC) before and after an ECT course, without characterizing functional changes occurring at early treatment phases. Objective: To assess sequential changes in limbic and prefrontal FC during the course of ECT and their impact on clinical response. Methods: Longitudinal intralimbic and limbic–prefrontal networks connectivity study. We assessed 15 patients with treatment-resistant depression at four different time-points throughout the entire course of an ECT protocol and 10 healthy participants at two functional neuroimaging examinations. Furthermore, a path analysis to test direct and indirect predictive effects of limbic and prefrontal FC changes on clinical response measured with the Hamilton Rating Scale for Depression was also performed. Results: An early significant intralimbic FC decrease significantly predicted a later increase in limbic–prefrontal FC, which in turn significantly predicted clinical improvement at the end of an ECT course. Conclusions: Our data support that treatment response involves sequential changes in FC within regions of the intralimbic and limbic–prefrontal networks. This approach may help in identifying potential early biomarkers of treatment response.http://www.sciencedirect.com/science/article/pii/S1935861X15011171Electroconvulsive therapyTreatment-resistant depressionIntralimbic modulationLimbic–prefrontal modulationTreatment early biomarkers |