Dynamic cross talk model of the epithelial innate immune response to double-stranded RNA stimulation: coordinated dynamics emerging from cell-level noise.

Dynamic cross talk model of the epithelial innate immune response to double-stranded RNA stimulation: coordinated dynamics emerging from cell-level noise.

We present an integrated dynamical cross-talk model of the epithelial innate immune response (IIR) incorporating RIG-I and TLR3 as the two major pattern recognition receptors (PRR) converging on the RelA and IRF3 transcriptional effectors. bioPN simulations reproduce biologically relevant gene-and p...

Full description

Bibliographic Details
Main Authors: Roberto Bertolusso, Bing Tian, Yingxin Zhao, Leoncio Vergara, Aqeeb Sabree, Marta Iwanaszko, Tomasz Lipniacki, Allan R Brasier, Marek Kimmel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3977818?pdf=render

Similar Items

Similar Items