High Blood Pressure Is Associated with Tubulointerstitial Damage along with Glomerular Damage in Glomerulonephritis. A large Cohort Study
The key role of arterial hypertension in chonic kidney disease (CKD) progression is widely recognized, but its contribution to tubulointerstitial damage (TID) in glomerulonephritis (GN) remains uncertain. Hence, the objective of this study is to clarify whether TID is associated with glomerular dama...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-06-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/9/6/1656 |
id |
doaj-e217f5b51f1c456189040963c8890e77 |
---|---|
record_format |
Article |
spelling |
doaj-e217f5b51f1c456189040963c8890e772020-11-25T02:51:54ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0191656165610.3390/jcm9061656High Blood Pressure Is Associated with Tubulointerstitial Damage along with Glomerular Damage in Glomerulonephritis. A large Cohort StudyClaudio Bazzi0Teresa M Seccia1Pietro Napodano2Cristina Campi3Brasilina Caroccia4Leda Cattarin5Lorenzo A Calò6D’Amico Foundation for Renal Disease Research, 20145 Milan, ItalyHypertension Unit, Department of Medicine—DIMED, University of Padova, 35128 Padova, ItalyNephrology and Dialysis Unit, Azienda Ospedaliera Ospedale San Carlo Borromeo, 20153 Milano, ItalyDepartment of Mathematics, University of Padova, 35121 Padova, ItalyHypertension Unit, Department of Medicine—DIMED, University of Padova, 35128 Padova, ItalyNephrology, Dialysis and Trasplantation Unit, Department of Medicine—DIMED, University of Padova, 35128 Padova, ItalyNephrology, Dialysis and Trasplantation Unit, Department of Medicine—DIMED, University of Padova, 35128 Padova, ItalyThe key role of arterial hypertension in chonic kidney disease (CKD) progression is widely recognized, but its contribution to tubulointerstitial damage (TID) in glomerulonephritis (GN) remains uncertain. Hence, the objective of this study is to clarify whether TID is associated with glomerular damage, and whether the damage at the tubulointerstitial compartment is more severe in hypertensive patients. The study included retrospectively consecutive patients referred to the Nephrology Unit with diagnoses of primary glomerulonephritis, lupus nephritis (LN), and nephroangiosclerosis (NAS) at biopsy. At least six glomeruli per biopsy were analysed through light and immunofluorescence microscopy. Global glomerulosclerosis (GGS%), TID, and arteriolar hyalinosis (AH) were used as markers of CKD severity. Of the 448 patients of the cohort, 403 received a diagnosis of GN, with the remaining being diagnosed with NAS. Hypertension was found in 52% of the overall patients, with no significant differences among those with GN, and reaching 88.9% prevalence rate in NAS. The hypertensive patients with GN had more marked damage in glomerular and tubular compartments than normotensives independently of the amount of proteinuria. Moreover, hypertension and GGS% were found to be strongly associated with TID in GN. In GN patients, not only the severity of glomerular damage but also the extent of TID was associated with high blood pressure.https://www.mdpi.com/2077-0383/9/6/1656glomerulartubulointerstitial damagekidneyhypertensionproteinuria |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Claudio Bazzi Teresa M Seccia Pietro Napodano Cristina Campi Brasilina Caroccia Leda Cattarin Lorenzo A Calò |
spellingShingle |
Claudio Bazzi Teresa M Seccia Pietro Napodano Cristina Campi Brasilina Caroccia Leda Cattarin Lorenzo A Calò High Blood Pressure Is Associated with Tubulointerstitial Damage along with Glomerular Damage in Glomerulonephritis. A large Cohort Study Journal of Clinical Medicine glomerular tubulointerstitial damage kidney hypertension proteinuria |
author_facet |
Claudio Bazzi Teresa M Seccia Pietro Napodano Cristina Campi Brasilina Caroccia Leda Cattarin Lorenzo A Calò |
author_sort |
Claudio Bazzi |
title |
High Blood Pressure Is Associated with Tubulointerstitial Damage along with Glomerular Damage in Glomerulonephritis. A large Cohort Study |
title_short |
High Blood Pressure Is Associated with Tubulointerstitial Damage along with Glomerular Damage in Glomerulonephritis. A large Cohort Study |
title_full |
High Blood Pressure Is Associated with Tubulointerstitial Damage along with Glomerular Damage in Glomerulonephritis. A large Cohort Study |
title_fullStr |
High Blood Pressure Is Associated with Tubulointerstitial Damage along with Glomerular Damage in Glomerulonephritis. A large Cohort Study |
title_full_unstemmed |
High Blood Pressure Is Associated with Tubulointerstitial Damage along with Glomerular Damage in Glomerulonephritis. A large Cohort Study |
title_sort |
high blood pressure is associated with tubulointerstitial damage along with glomerular damage in glomerulonephritis. a large cohort study |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-06-01 |
description |
The key role of arterial hypertension in chonic kidney disease (CKD) progression is widely recognized, but its contribution to tubulointerstitial damage (TID) in glomerulonephritis (GN) remains uncertain. Hence, the objective of this study is to clarify whether TID is associated with glomerular damage, and whether the damage at the tubulointerstitial compartment is more severe in hypertensive patients. The study included retrospectively consecutive patients referred to the Nephrology Unit with diagnoses of primary glomerulonephritis, lupus nephritis (LN), and nephroangiosclerosis (NAS) at biopsy. At least six glomeruli per biopsy were analysed through light and immunofluorescence microscopy. Global glomerulosclerosis (GGS%), TID, and arteriolar hyalinosis (AH) were used as markers of CKD severity. Of the 448 patients of the cohort, 403 received a diagnosis of GN, with the remaining being diagnosed with NAS. Hypertension was found in 52% of the overall patients, with no significant differences among those with GN, and reaching 88.9% prevalence rate in NAS. The hypertensive patients with GN had more marked damage in glomerular and tubular compartments than normotensives independently of the amount of proteinuria. Moreover, hypertension and GGS% were found to be strongly associated with TID in GN. In GN patients, not only the severity of glomerular damage but also the extent of TID was associated with high blood pressure. |
topic |
glomerular tubulointerstitial damage kidney hypertension proteinuria |
url |
https://www.mdpi.com/2077-0383/9/6/1656 |
work_keys_str_mv |
AT claudiobazzi highbloodpressureisassociatedwithtubulointerstitialdamagealongwithglomerulardamageinglomerulonephritisalargecohortstudy AT teresamseccia highbloodpressureisassociatedwithtubulointerstitialdamagealongwithglomerulardamageinglomerulonephritisalargecohortstudy AT pietronapodano highbloodpressureisassociatedwithtubulointerstitialdamagealongwithglomerulardamageinglomerulonephritisalargecohortstudy AT cristinacampi highbloodpressureisassociatedwithtubulointerstitialdamagealongwithglomerulardamageinglomerulonephritisalargecohortstudy AT brasilinacaroccia highbloodpressureisassociatedwithtubulointerstitialdamagealongwithglomerulardamageinglomerulonephritisalargecohortstudy AT ledacattarin highbloodpressureisassociatedwithtubulointerstitialdamagealongwithglomerulardamageinglomerulonephritisalargecohortstudy AT lorenzoacalo highbloodpressureisassociatedwithtubulointerstitialdamagealongwithglomerulardamageinglomerulonephritisalargecohortstudy |
_version_ |
1724732731552694272 |