Conjugated secondary 12α-hydroxylated bile acids promote liver fibrogenesis

Conjugated secondary 12α-hydroxylated bile acids promote liver fibrogenesis

Background: Significantly elevated serum and hepatic bile acid (BA) concentrations have been known to occur in patients with liver fibrosis. However, the roles of different BA species in liver fibrogenesis are not fully understood. Methods: We quantitatively measured blood BA concentrations in nonal...

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Bibliographic Details
Main Authors:	Guoxiang Xie, Runqiu Jiang, Xiaoning Wang, Ping Liu, Aihua Zhao, Yiran Wu, Fengjie Huang, Zhipeng Liu, Cynthia Rajani, Xiaojiao Zheng, Jiannan Qiu, Xiaoling Zhang, Suwen Zhao, Hua Bian, Xin Gao, Beicheng Sun, Wei Jia
Format:	Article
Language:	English
Published:	Elsevier 2021-04-01
Series:	EBioMedicine
Subjects:	Liver fibrosis Hepatic stellate cell 12α-hydroxylated bile acids G protein-coupled bile acid receptor TGR5 p38MAPK
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396421000839

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