Mammaglobin mRNA expression as early breast cancer marker

• Main Authors: V Konstantinovich Bojenko, V Alekseevich Solodky, N Vladimirovna Kharchenko, I Dmitrievich Trotsenko, D Yur'evich Trofimov, E Aleksandrovna Kudinova, E Fedorovna Vaskevich, O V Burmenskaya
• Format: Article
• Language: English
• Published: Peoples’ Friendship University of Russia (RUDN University) 2013-12-01
• Series: RUDN Journal of Medicine
• Subjects: рак молочной железы; опухолевая прогрессия; экспрессия мРНК; маммаглобин; утероглобин
• Online Access: http://journals.rudn.ru/medicine/article/view/3249
• ISSN: 2313-0245; 2313-0261

Early breast cancer (BC) diagnosis is a basis for overall and relapse-free survival improvement. But methods of X-ray and morphological examination sometimes are failed in BC diagnosis. New molecular markers may give more information about BC progression. One of these markers is mammaglobin. We studied 114 tissue samples: 57 I—IV stages BC samples and 57 samples of morphologically normal breast tissue (MNBT). mRNA mammaglobin expression was assessed by qPCR with reverse transcription. mRAN mammaglobin expression was significantly higher in BC samples as compared to MNBT (p = 0,0019), besides expression level decreased during BC progression: minimal level in T3 (p = 0,0338), grade 3 (p = 0,037) and stage IV (p = 0,035) tumors. hMAM expression correlated with steroid receptors (estrogen receptor, progesterone receptpor) in MNBT (p < 0.05), but not in BC tissue. hMAM mRNA expression decreased during BC progression and correlated with steroid receptors in MNBT. hMAM expression profiling may be used as a marker in BC diagnosis.