Mammaglobin mRNA expression as early breast cancer marker
Early breast cancer (BC) diagnosis is a basis for overall and relapse-free survival improvement. But methods of X-ray and morphological examination sometimes are failed in BC diagnosis. New molecular markers may give more information about BC progression. One of these markers is mammaglobin. We stud...
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Peoples’ Friendship University of Russia (RUDN University)
2013-12-01
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doaj-e220526bd07f468693f023516b113e9f2020-11-24T23:53:11ZengPeoples’ Friendship University of Russia (RUDN University)RUDN Journal of Medicine2313-02452313-02612013-12-010271773249Mammaglobin mRNA expression as early breast cancer markerV Konstantinovich Bojenko0V Alekseevich Solodky1N Vladimirovna Kharchenko2I Dmitrievich Trotsenko3D Yur'evich Trofimov4E Aleksandrovna Kudinova5E Fedorovna Vaskevich6O V Burmenskaya7ФГБУ РНЦРР Минздрава РФФГБУ РНЦРР Минздрава РФРоссийский университет дружбы народовРоссийский университет дружбы народовОАО «ДНК-технология»ФГБУ РНЦРР Минздрава РФФГБУ РНЦРР Минздрава РФНаучный центр акушерства, гинекологии и перинатологии РАМНEarly breast cancer (BC) diagnosis is a basis for overall and relapse-free survival improvement. But methods of X-ray and morphological examination sometimes are failed in BC diagnosis. New molecular markers may give more information about BC progression. One of these markers is mammaglobin. We studied 114 tissue samples: 57 I—IV stages BC samples and 57 samples of morphologically normal breast tissue (MNBT). mRNA mammaglobin expression was assessed by qPCR with reverse transcription. mRAN mammaglobin expression was significantly higher in BC samples as compared to MNBT (p = 0,0019), besides expression level decreased during BC progression: minimal level in T3 (p = 0,0338), grade 3 (p = 0,037) and stage IV (p = 0,035) tumors. hMAM expression correlated with steroid receptors (estrogen receptor, progesterone receptpor) in MNBT (p < 0.05), but not in BC tissue. hMAM mRNA expression decreased during BC progression and correlated with steroid receptors in MNBT. hMAM expression profiling may be used as a marker in BC diagnosis.http://journals.rudn.ru/medicine/article/view/3249рак молочной железыопухолевая прогрессияэкспрессия мРНКмаммаглобинутероглобин |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
V Konstantinovich Bojenko V Alekseevich Solodky N Vladimirovna Kharchenko I Dmitrievich Trotsenko D Yur'evich Trofimov E Aleksandrovna Kudinova E Fedorovna Vaskevich O V Burmenskaya |
spellingShingle |
V Konstantinovich Bojenko V Alekseevich Solodky N Vladimirovna Kharchenko I Dmitrievich Trotsenko D Yur'evich Trofimov E Aleksandrovna Kudinova E Fedorovna Vaskevich O V Burmenskaya Mammaglobin mRNA expression as early breast cancer marker RUDN Journal of Medicine рак молочной железы опухолевая прогрессия экспрессия мРНК маммаглобин утероглобин |
author_facet |
V Konstantinovich Bojenko V Alekseevich Solodky N Vladimirovna Kharchenko I Dmitrievich Trotsenko D Yur'evich Trofimov E Aleksandrovna Kudinova E Fedorovna Vaskevich O V Burmenskaya |
author_sort |
V Konstantinovich Bojenko |
title |
Mammaglobin mRNA expression as early breast cancer marker |
title_short |
Mammaglobin mRNA expression as early breast cancer marker |
title_full |
Mammaglobin mRNA expression as early breast cancer marker |
title_fullStr |
Mammaglobin mRNA expression as early breast cancer marker |
title_full_unstemmed |
Mammaglobin mRNA expression as early breast cancer marker |
title_sort |
mammaglobin mrna expression as early breast cancer marker |
publisher |
Peoples’ Friendship University of Russia (RUDN University) |
series |
RUDN Journal of Medicine |
issn |
2313-0245 2313-0261 |
publishDate |
2013-12-01 |
description |
Early breast cancer (BC) diagnosis is a basis for overall and relapse-free survival improvement. But methods of X-ray and morphological examination sometimes are failed in BC diagnosis. New molecular markers may give more information about BC progression. One of these markers is mammaglobin. We studied 114 tissue samples: 57 I—IV stages BC samples and 57 samples of morphologically normal breast tissue (MNBT). mRNA mammaglobin expression was assessed by qPCR with reverse transcription. mRAN mammaglobin expression was significantly higher in BC samples as compared to MNBT (p = 0,0019), besides expression level decreased during BC progression: minimal level in T3 (p = 0,0338), grade 3 (p = 0,037) and stage IV (p = 0,035) tumors. hMAM expression correlated with steroid receptors (estrogen receptor, progesterone receptpor) in MNBT (p < 0.05), but not in BC tissue. hMAM mRNA expression decreased during BC progression and correlated with steroid receptors in MNBT. hMAM expression profiling may be used as a marker in BC diagnosis. |
topic |
рак молочной железы опухолевая прогрессия экспрессия мРНК маммаглобин утероглобин |
url |
http://journals.rudn.ru/medicine/article/view/3249 |
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