Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial
Joan Trabal,1 Maria Forga,1 Pere Leyes,1 Ferran Torres,2,3 Jordi Rubio,4 Esther Prieto,5 Andreu Farran-Codina6 1Department of Endocrinology and Nutrition, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain; 2Biostatistics and Data Management Core Facility, IDIBAPS, Ho...
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doaj-e221000dc9ad48e5b3bffc74f50f0fc52020-11-24T20:41:28ZengDove Medical PressClinical Interventions in Aging1178-19982015-04-01Volume 1071372321290Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trialTrabal JForga MLeyes PTorres FRubio JPrieto EFarran-Codina AJoan Trabal,1 Maria Forga,1 Pere Leyes,1 Ferran Torres,2,3 Jordi Rubio,4 Esther Prieto,5 Andreu Farran-Codina6 1Department of Endocrinology and Nutrition, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain; 2Biostatistics and Data Management Core Facility, IDIBAPS, Hospital Clinic Universitari de Barcelona, Barcelona, Catalonia, Spain; 3Biostatistics Unit, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain; 4Residencia Ballesol Almogavers, Grupo Ballesol, Barcelona, Catalonia, Spain; 5Centre de Rehabilitacio, Fundació Amiba, Badalona, Catalonia, Spain; 6Department of Nutrition and Food Science, Faculty of Pharmacy, Universitat de Barcelona, Barcelona, Catalonia, Spain Objective: To assess the effect of free leucine supplementation combined with resistance training versus resistance training only on muscle strength and functional status in older adults.Methods: This was a randomized, double-blind, placebo-controlled, parallel study with two intervention groups. Thirty older adults were randomly assigned to receive either 10 g leucine/day (leucine group [LG], n=15) or a placebo (control group [CG], n=15), plus resistance training over a 12-week period. Maximal overcoming isometric leg strength, functional status, nutritional status, body composition, health-related quality of life, depression, and dietary intake were assessed at 4 and 12 weeks. Missing data at 12 weeks were handled using mixed models for repeated measurements for data imputation.Results: Twenty-four subjects completed the 4-week assessment and eleven completed the 12-week intervention. Clinically significant gains were found in isometric leg strength at both assessment time points. Analysis of the effect size also showed how participants in LG outperformed those in CG for chair stands and the timed up and go test. No significant changes were observed for the rest of the outcomes.Conclusion: Our combined analysis showed moderate changes in isometric leg muscle strength and certain components of functional status. The magnitude of changes found on these outcomes should be qualified as a positive effect of the concomitant intervention. Keywords: aged, elderly, strength training, amino acid, functionalityhttps://www.dovepress.com/effects-of-free-leucine-supplementation-and-resistance-training-on-mus-peer-reviewed-article-CIALeucineResistance TrainingAgedMuscle StrengthFunctional Status |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Trabal J Forga M Leyes P Torres F Rubio J Prieto E Farran-Codina A |
spellingShingle |
Trabal J Forga M Leyes P Torres F Rubio J Prieto E Farran-Codina A Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial Clinical Interventions in Aging Leucine Resistance Training Aged Muscle Strength Functional Status |
author_facet |
Trabal J Forga M Leyes P Torres F Rubio J Prieto E Farran-Codina A |
author_sort |
Trabal J |
title |
Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial |
title_short |
Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial |
title_full |
Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial |
title_fullStr |
Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial |
title_full_unstemmed |
Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial |
title_sort |
effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial |
publisher |
Dove Medical Press |
series |
Clinical Interventions in Aging |
issn |
1178-1998 |
publishDate |
2015-04-01 |
description |
Joan Trabal,1 Maria Forga,1 Pere Leyes,1 Ferran Torres,2,3 Jordi Rubio,4 Esther Prieto,5 Andreu Farran-Codina6 1Department of Endocrinology and Nutrition, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain; 2Biostatistics and Data Management Core Facility, IDIBAPS, Hospital Clinic Universitari de Barcelona, Barcelona, Catalonia, Spain; 3Biostatistics Unit, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain; 4Residencia Ballesol Almogavers, Grupo Ballesol, Barcelona, Catalonia, Spain; 5Centre de Rehabilitacio, Fundació Amiba, Badalona, Catalonia, Spain; 6Department of Nutrition and Food Science, Faculty of Pharmacy, Universitat de Barcelona, Barcelona, Catalonia, Spain Objective: To assess the effect of free leucine supplementation combined with resistance training versus resistance training only on muscle strength and functional status in older adults.Methods: This was a randomized, double-blind, placebo-controlled, parallel study with two intervention groups. Thirty older adults were randomly assigned to receive either 10 g leucine/day (leucine group [LG], n=15) or a placebo (control group [CG], n=15), plus resistance training over a 12-week period. Maximal overcoming isometric leg strength, functional status, nutritional status, body composition, health-related quality of life, depression, and dietary intake were assessed at 4 and 12 weeks. Missing data at 12 weeks were handled using mixed models for repeated measurements for data imputation.Results: Twenty-four subjects completed the 4-week assessment and eleven completed the 12-week intervention. Clinically significant gains were found in isometric leg strength at both assessment time points. Analysis of the effect size also showed how participants in LG outperformed those in CG for chair stands and the timed up and go test. No significant changes were observed for the rest of the outcomes.Conclusion: Our combined analysis showed moderate changes in isometric leg muscle strength and certain components of functional status. The magnitude of changes found on these outcomes should be qualified as a positive effect of the concomitant intervention. Keywords: aged, elderly, strength training, amino acid, functionality |
topic |
Leucine Resistance Training Aged Muscle Strength Functional Status |
url |
https://www.dovepress.com/effects-of-free-leucine-supplementation-and-resistance-training-on-mus-peer-reviewed-article-CIA |
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