Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease
Formerly considered as a passive process, the resolution of acute inflammation is now recognized as an active host response, with a cascade of coordinated cellular and molecular events that promotes termination of the inflammatory response and initiates tissue repair and healing. In a state of immun...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2019-07-01
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Series: | Frontiers in Immunology |
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Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01699/full |
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doaj-e22a69007dc74cafac4e6bd08cf70cb7 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cindy Barnig Cindy Barnig Tjitske Bezema Philip C. Calder Philip C. Calder Anne Charloux Anne Charloux Nelly Frossard Johan Garssen Johan Garssen Oliver Haworth Ksenia Dilevskaya Francesca Levi-Schaffer Evelyne Lonsdorfer Evelyne Lonsdorfer Marca Wauben Aletta D. Kraneveld Aletta D. Kraneveld Anje A. te Velde |
spellingShingle |
Cindy Barnig Cindy Barnig Tjitske Bezema Philip C. Calder Philip C. Calder Anne Charloux Anne Charloux Nelly Frossard Johan Garssen Johan Garssen Oliver Haworth Ksenia Dilevskaya Francesca Levi-Schaffer Evelyne Lonsdorfer Evelyne Lonsdorfer Marca Wauben Aletta D. Kraneveld Aletta D. Kraneveld Anje A. te Velde Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease Frontiers in Immunology resolution inflammation immune fitness eicosanoids asthma chronic inflammatory bowel disease |
author_facet |
Cindy Barnig Cindy Barnig Tjitske Bezema Philip C. Calder Philip C. Calder Anne Charloux Anne Charloux Nelly Frossard Johan Garssen Johan Garssen Oliver Haworth Ksenia Dilevskaya Francesca Levi-Schaffer Evelyne Lonsdorfer Evelyne Lonsdorfer Marca Wauben Aletta D. Kraneveld Aletta D. Kraneveld Anje A. te Velde |
author_sort |
Cindy Barnig |
title |
Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease |
title_short |
Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease |
title_full |
Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease |
title_fullStr |
Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease |
title_full_unstemmed |
Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease |
title_sort |
activation of resolution pathways to prevent and fight chronic inflammation: lessons from asthma and inflammatory bowel disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2019-07-01 |
description |
Formerly considered as a passive process, the resolution of acute inflammation is now recognized as an active host response, with a cascade of coordinated cellular and molecular events that promotes termination of the inflammatory response and initiates tissue repair and healing. In a state of immune fitness, the resolution of inflammation is contained in time and space enabling the restoration of tissue homeostasis. There is increasing evidence that poor and/or inappropriate resolution of inflammation participates in the pathogenesis of chronic inflammatory diseases, extending in time the actions of pro-inflammatory mechanisms, and responsible in the long run for excessive tissue damage and pathology. In this review, we will focus on how resolution can be the target for therapy in “Th1/Th17 cell-driven” immune diseases and “Th2 cell-driven” immune diseases, with inflammatory bowel diseases (IBD) and asthma, as relevant examples. We describe the main cells and mediators stimulating the resolution of inflammation and discuss how pharmacological and dietary interventions but also life style factors, physical and psychological conditions, might influence the resolution phase. A better understanding of the impact of endogenous and exogenous factors on the resolution of inflammation might open a whole area in the development of personalized therapies in non-resolving chronic inflammatory diseases. |
topic |
resolution inflammation immune fitness eicosanoids asthma chronic inflammatory bowel disease |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2019.01699/full |
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doaj-e22a69007dc74cafac4e6bd08cf70cb72020-11-25T00:12:12ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-07-011010.3389/fimmu.2019.01699435325Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel DiseaseCindy Barnig0Cindy Barnig1Tjitske Bezema2Philip C. Calder3Philip C. Calder4Anne Charloux5Anne Charloux6Nelly Frossard7Johan Garssen8Johan Garssen9Oliver Haworth10Ksenia Dilevskaya11Francesca Levi-Schaffer12Evelyne Lonsdorfer13Evelyne Lonsdorfer14Marca Wauben15Aletta D. Kraneveld16Aletta D. Kraneveld17Anje A. te Velde18Department of Chest Disease, Strasbourg University Hospital, Strasbourg, FranceEquipe d'accueil 3072, University of Strasbourg, Strasbourg, FranceImmunowell Foundation, Utrecht, NetherlandsHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, United KingdomNational Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, United KingdomDepartment of Chest Disease, Strasbourg University Hospital, Strasbourg, FranceEquipe d'accueil 3072, University of Strasbourg, Strasbourg, FranceUMR 7200 CNRS/Université de Strasbourg, Laboratoire d'Innovation Thérapeutique and LabEx MEDALIS, Faculté de Pharmacie, Strasbourg, FranceDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, NetherlandsNutricia Research, Utrecht, NetherlandsBiochemical Pharmacology, William Harvey Research Institute, Bart's School of Medicine and Queen Mary University of London, London, United Kingdom0Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands1Pharmacology and Experimental Therapeutics Unit, Faculty of Medicine, School of Pharmacy, Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, IsraelDepartment of Chest Disease, Strasbourg University Hospital, Strasbourg, FranceEquipe d'accueil 3072, University of Strasbourg, Strasbourg, France2Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, NetherlandsDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands3Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands4Amsterdam UMC, Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, AGEM, Amsterdam, NetherlandsFormerly considered as a passive process, the resolution of acute inflammation is now recognized as an active host response, with a cascade of coordinated cellular and molecular events that promotes termination of the inflammatory response and initiates tissue repair and healing. In a state of immune fitness, the resolution of inflammation is contained in time and space enabling the restoration of tissue homeostasis. There is increasing evidence that poor and/or inappropriate resolution of inflammation participates in the pathogenesis of chronic inflammatory diseases, extending in time the actions of pro-inflammatory mechanisms, and responsible in the long run for excessive tissue damage and pathology. In this review, we will focus on how resolution can be the target for therapy in “Th1/Th17 cell-driven” immune diseases and “Th2 cell-driven” immune diseases, with inflammatory bowel diseases (IBD) and asthma, as relevant examples. We describe the main cells and mediators stimulating the resolution of inflammation and discuss how pharmacological and dietary interventions but also life style factors, physical and psychological conditions, might influence the resolution phase. A better understanding of the impact of endogenous and exogenous factors on the resolution of inflammation might open a whole area in the development of personalized therapies in non-resolving chronic inflammatory diseases.https://www.frontiersin.org/article/10.3389/fimmu.2019.01699/fullresolutioninflammationimmune fitnesseicosanoidsasthmachronic inflammatory bowel disease |