Amine-Rich Coatings to Potentially Promote Cell Adhesion, Proliferation and Differentiation, and Reduce Microbial Colonization: Strategies for Generation and Characterization
Biomaterial surface modification represents an important approach to obtain a better integration of the material in surrounding tissues. Different techniques are focused on improving cell support as well as avoiding efficiently the development of infections, such as by modifying the biomaterial surf...
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MDPI AG
2021-08-01
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Online Access: | https://www.mdpi.com/2079-6412/11/8/983 |
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doaj-e22b985650e042559f059dcdf9e8c3d52021-08-26T13:38:53ZengMDPI AGCoatings2079-64122021-08-011198398310.3390/coatings11080983Amine-Rich Coatings to Potentially Promote Cell Adhesion, Proliferation and Differentiation, and Reduce Microbial Colonization: Strategies for Generation and CharacterizationLaurine Martocq0Timothy E. L. Douglas1Engineering Department, Lancaster University, Lancaster LA1 4YW, UKEngineering Department, Lancaster University, Lancaster LA1 4YW, UKBiomaterial surface modification represents an important approach to obtain a better integration of the material in surrounding tissues. Different techniques are focused on improving cell support as well as avoiding efficiently the development of infections, such as by modifying the biomaterial surface with amine groups (–NH<sub>2</sub>). Previous studies showed that –NH<sub>2</sub> groups could promote cell adhesion and proliferation. Moreover, these chemical functionalities may be used to facilitate the attachment of molecules such as proteins or to endow antimicrobial properties. This mini-review gives an overview of different techniques which have been used to obtain amine-rich coatings such as plasma methods and adsorption of biomolecules. In fact, different plasma treatment methods are commonly used with ammonia gas or by polymerization of precursors such as allylamine, as well as coatings of proteins (for example, collagen) or polymers containing –NH<sub>2</sub> groups (for example, polyethyleneimine). Moreover, this mini-review will present the methods used to characterize such coatings and, in particular, quantify the –NH<sub>2</sub> groups present on the surface by using dyes or chemical derivatization methods.https://www.mdpi.com/2079-6412/11/8/983amine groupscoatingssurface characterizationantimicrobialcell behavior |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laurine Martocq Timothy E. L. Douglas |
spellingShingle |
Laurine Martocq Timothy E. L. Douglas Amine-Rich Coatings to Potentially Promote Cell Adhesion, Proliferation and Differentiation, and Reduce Microbial Colonization: Strategies for Generation and Characterization Coatings amine groups coatings surface characterization antimicrobial cell behavior |
author_facet |
Laurine Martocq Timothy E. L. Douglas |
author_sort |
Laurine Martocq |
title |
Amine-Rich Coatings to Potentially Promote Cell Adhesion, Proliferation and Differentiation, and Reduce Microbial Colonization: Strategies for Generation and Characterization |
title_short |
Amine-Rich Coatings to Potentially Promote Cell Adhesion, Proliferation and Differentiation, and Reduce Microbial Colonization: Strategies for Generation and Characterization |
title_full |
Amine-Rich Coatings to Potentially Promote Cell Adhesion, Proliferation and Differentiation, and Reduce Microbial Colonization: Strategies for Generation and Characterization |
title_fullStr |
Amine-Rich Coatings to Potentially Promote Cell Adhesion, Proliferation and Differentiation, and Reduce Microbial Colonization: Strategies for Generation and Characterization |
title_full_unstemmed |
Amine-Rich Coatings to Potentially Promote Cell Adhesion, Proliferation and Differentiation, and Reduce Microbial Colonization: Strategies for Generation and Characterization |
title_sort |
amine-rich coatings to potentially promote cell adhesion, proliferation and differentiation, and reduce microbial colonization: strategies for generation and characterization |
publisher |
MDPI AG |
series |
Coatings |
issn |
2079-6412 |
publishDate |
2021-08-01 |
description |
Biomaterial surface modification represents an important approach to obtain a better integration of the material in surrounding tissues. Different techniques are focused on improving cell support as well as avoiding efficiently the development of infections, such as by modifying the biomaterial surface with amine groups (–NH<sub>2</sub>). Previous studies showed that –NH<sub>2</sub> groups could promote cell adhesion and proliferation. Moreover, these chemical functionalities may be used to facilitate the attachment of molecules such as proteins or to endow antimicrobial properties. This mini-review gives an overview of different techniques which have been used to obtain amine-rich coatings such as plasma methods and adsorption of biomolecules. In fact, different plasma treatment methods are commonly used with ammonia gas or by polymerization of precursors such as allylamine, as well as coatings of proteins (for example, collagen) or polymers containing –NH<sub>2</sub> groups (for example, polyethyleneimine). Moreover, this mini-review will present the methods used to characterize such coatings and, in particular, quantify the –NH<sub>2</sub> groups present on the surface by using dyes or chemical derivatization methods. |
topic |
amine groups coatings surface characterization antimicrobial cell behavior |
url |
https://www.mdpi.com/2079-6412/11/8/983 |
work_keys_str_mv |
AT laurinemartocq aminerichcoatingstopotentiallypromotecelladhesionproliferationanddifferentiationandreducemicrobialcolonizationstrategiesforgenerationandcharacterization AT timothyeldouglas aminerichcoatingstopotentiallypromotecelladhesionproliferationanddifferentiationandreducemicrobialcolonizationstrategiesforgenerationandcharacterization |
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