Endocrine therapy combined with targeted therapy in hormone receptor-positive metastatic breast cancer
Abstract. Increasing numbers of targeted drugs are used in hormone receptor (HR)-positive metastatic breast cancer (MBC) to overcome or delay resistance to endocrine therapy. This study will systemically review the progress made in endocrine therapy combined with targeted therapy in the treatment of...
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2020-10-01
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doaj-e248da5a2b864f1f82692db1474420af2020-12-02T08:02:06ZengWolters KluwerChinese Medical Journal0366-69992542-56412020-10-01133192338234510.1097/CM9.0000000000000923202010050-00014Endocrine therapy combined with targeted therapy in hormone receptor-positive metastatic breast cancerLi Bian0Feng-Rui Xu1Ze-Fei Jiang2Qiang Shi3Department of Breast Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China.Department of Breast Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China.Department of Breast Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China.Department of Breast Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China.Abstract. Increasing numbers of targeted drugs are used in hormone receptor (HR)-positive metastatic breast cancer (MBC) to overcome or delay resistance to endocrine therapy. This study will systemically review the progress made in endocrine therapy combined with targeted therapy in the treatment of HR-positive MBC. From the “AI (aromatase inhibitor) era” represented by aromatase inhibitors, we have gradually entered the “post-AI era” represented by fulvestrant. Under the guidance of research on the molecular mechanism of endocrine therapy resistance, the “combination of endocrine therapy and targeted therapy” era is approaching. The development of drugs that target endocrine therapy resistance has concentrated on cyclin-dependent kinase 4/6 inhibitors, histone deacetylase inhibitors, and inhibitors of drug targets in the phosphatidylinositol 3 kinase-protein kinase B-mammalian target of rapamycin (PI3K-AKT-mTOR) pathway, providing new strategies for HR-positive MBC. Exploring biomarkers to guide the more precise use of targeted drugs in endocrine therapy for MBC is the focus of current and future research.http://journals.lww.com/10.1097/CM9.0000000000000923 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li Bian Feng-Rui Xu Ze-Fei Jiang Qiang Shi |
spellingShingle |
Li Bian Feng-Rui Xu Ze-Fei Jiang Qiang Shi Endocrine therapy combined with targeted therapy in hormone receptor-positive metastatic breast cancer Chinese Medical Journal |
author_facet |
Li Bian Feng-Rui Xu Ze-Fei Jiang Qiang Shi |
author_sort |
Li Bian |
title |
Endocrine therapy combined with targeted therapy in hormone receptor-positive metastatic breast cancer |
title_short |
Endocrine therapy combined with targeted therapy in hormone receptor-positive metastatic breast cancer |
title_full |
Endocrine therapy combined with targeted therapy in hormone receptor-positive metastatic breast cancer |
title_fullStr |
Endocrine therapy combined with targeted therapy in hormone receptor-positive metastatic breast cancer |
title_full_unstemmed |
Endocrine therapy combined with targeted therapy in hormone receptor-positive metastatic breast cancer |
title_sort |
endocrine therapy combined with targeted therapy in hormone receptor-positive metastatic breast cancer |
publisher |
Wolters Kluwer |
series |
Chinese Medical Journal |
issn |
0366-6999 2542-5641 |
publishDate |
2020-10-01 |
description |
Abstract. Increasing numbers of targeted drugs are used in hormone receptor (HR)-positive metastatic breast cancer (MBC) to overcome or delay resistance to endocrine therapy. This study will systemically review the progress made in endocrine therapy combined with targeted therapy in the treatment of HR-positive MBC. From the “AI (aromatase inhibitor) era” represented by aromatase inhibitors, we have gradually entered the “post-AI era” represented by fulvestrant. Under the guidance of research on the molecular mechanism of endocrine therapy resistance, the “combination of endocrine therapy and targeted therapy” era is approaching. The development of drugs that target endocrine therapy resistance has concentrated on cyclin-dependent kinase 4/6 inhibitors, histone deacetylase inhibitors, and inhibitors of drug targets in the phosphatidylinositol 3 kinase-protein kinase B-mammalian target of rapamycin (PI3K-AKT-mTOR) pathway, providing new strategies for HR-positive MBC. Exploring biomarkers to guide the more precise use of targeted drugs in endocrine therapy for MBC is the focus of current and future research. |
url |
http://journals.lww.com/10.1097/CM9.0000000000000923 |
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