The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation

The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation

The membrane-associated RING-CH-type finger (MARCH) proteins of E3 ubiquitin ligases have emerged as critical regulators of immune responses. MARCH proteins target immune receptors, viral proteins as well as components in innate immune response for polyubiquitination and degradations via distinct ro...

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Bibliographic Details
Main Authors: Heng Lin, Shu Li, Hong-Bing Shu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
MARCH proteins
E3 ligase
ubiquitination
immune regulation
immune receptors
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01751/full
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spelling doaj-e258e8e23f084de987bceb0d5d24d9a12020-11-25T01:26:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-07-011010.3389/fimmu.2019.01751469435The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune RegulationHeng LinShu LiHong-Bing ShuThe membrane-associated RING-CH-type finger (MARCH) proteins of E3 ubiquitin ligases have emerged as critical regulators of immune responses. MARCH proteins target immune receptors, viral proteins as well as components in innate immune response for polyubiquitination and degradations via distinct routes. This review summarizes the current progress about MARCH proteins and their regulation on immune responses.https://www.frontiersin.org/article/10.3389/fimmu.2019.01751/fullMARCH proteinsE3 ligaseubiquitinationimmune regulationimmune receptors
collection DOAJ
language English
format Article
sources DOAJ
author Heng Lin
Shu Li
Hong-Bing Shu
spellingShingle Heng Lin
Shu Li
Hong-Bing Shu
The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation
Frontiers in Immunology
MARCH proteins
E3 ligase
ubiquitination
immune regulation
immune receptors
author_facet Heng Lin
Shu Li
Hong-Bing Shu
author_sort Heng Lin
title The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation
title_short The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation
title_full The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation
title_fullStr The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation
title_full_unstemmed The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation
title_sort membrane-associated march e3 ligase family: emerging roles in immune regulation
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2019-07-01
description The membrane-associated RING-CH-type finger (MARCH) proteins of E3 ubiquitin ligases have emerged as critical regulators of immune responses. MARCH proteins target immune receptors, viral proteins as well as components in innate immune response for polyubiquitination and degradations via distinct routes. This review summarizes the current progress about MARCH proteins and their regulation on immune responses.
topic MARCH proteins
E3 ligase
ubiquitination
immune regulation
immune receptors
url https://www.frontiersin.org/article/10.3389/fimmu.2019.01751/full
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