Elevated Levels of Apolipoprotein CIII Increase the Risk of Postprandial Hypertriglyceridemia
BackgroundTo investigate possible mechanisms of postprandial hypertriglyceridemia (PPT), we analyzed serum lipid and apolipoprotein (Apo) AI, B, CII and CIII levels before and after a high-fat meal.MethodsThe study has been registered with the China Clinical Trial Registry (registration number:ChiCT...
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doaj-e25adee8a9ae44b8a096419ac73b63ca2021-04-23T08:15:05ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-04-011210.3389/fendo.2021.646185646185Elevated Levels of Apolipoprotein CIII Increase the Risk of Postprandial HypertriglyceridemiaYunpeng Guan0Yunpeng Guan1Xiaoyu Hou2Xiaoyu Hou3Peipei Tian4Luping Ren5Yong Tang6An Song7Jiajun Zhao8Ling Gao9Guangyao Song10Guangyao Song11Department of Internal Medicine, Hebei Medical University, Shijiazhuang, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang, ChinaDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang, ChinaDepartment of Endocrinology, Cangzhou Central Hospital, Cangzhou, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang, ChinaKey Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Endocrinology and Metabolism, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, ChinaDepartment of Endocrinology and Metabolism, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, ChinaDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang, ChinaDepartment of Endocrinology, Hebei General Hospital, Shijiazhuang, ChinaBackgroundTo investigate possible mechanisms of postprandial hypertriglyceridemia (PPT), we analyzed serum lipid and apolipoprotein (Apo) AI, B, CII and CIII levels before and after a high-fat meal.MethodsThe study has been registered with the China Clinical Trial Registry (registration number:ChiCTR1800019514; URL: http://www.chictr.org.cn/index.aspx). We recruited 143 volunteers with normal fasting triglyceride (TG) levels. All subjects consumed a high-fat test meal. Venous blood samples were obtained during fasting and at 2, 4, and 6 hours after the high-fat meal. PPT was defined as TG ≥2.5 mmol/L any time after the meal. Subjects were divided into two groups according to the high-fat meal test results: postprandial normal triglyceride (PNT) and PPT. We compared the fasting and postprandial lipid and ApoAI, ApoB, ApoCII and ApoCIII levels between the two groups.ResultsSignificant differences were found between the groups in fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), TG, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), TG-rich lipoprotein remnants (TRLRs), ApoB, ApoCIII, ApoAI/ApoB and ApoCII/ApoCIII. The insulin, HOMA-IR, TG, TC, LDL-C, non-HDL-C, TRLRs, ApoB, ApoCIII and ApoCII/ApoCIII values were higher in the PPT group, while the ApoAI/ApoB ratio was higher in the PNT group. The postprandial TG level peaked in the PNT group 2 hours after the meal but was significantly higher in the PPT group and peaked at 4 hours. TRLRs gradually increased within 6 hours after the high-fat meal in both groups. The area under the curve (AUC) of TG and TRLRs and the AUC increment were higher in the PPT group (P < 0.001). ApoCIII peaked in the PNT group 2 hours after the meal and gradually decreased. ApoCIII gradually increased in the PPT group within 6 hours after the meal, exhibiting a greater AUC increment (P < 0.001). Fasting ApoCIII was positively correlated with age, systolic and diastolic blood pressure, body mass index (BMI), waist circumference, TC, TG, LDL-C, non-HDL-C, TRLRs, and ApoB (P<0.05). ApoCIII was an independent risk factor of PPT after adjustment for BMI, waist circumference, TC, LDL-C, and ApoB (P < 0.001, OR=1.188).ConclusionsElevated ApoCIII levels may cause PPT.https://www.frontiersin.org/articles/10.3389/fendo.2021.646185/fulltriglyceridesdyslipidemiapostprandial hypertriglyceridemiatriglyceride-rich lipoprotein remnantsapolipoprotein CIII |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yunpeng Guan Yunpeng Guan Xiaoyu Hou Xiaoyu Hou Peipei Tian Luping Ren Yong Tang An Song Jiajun Zhao Ling Gao Guangyao Song Guangyao Song |
spellingShingle |
Yunpeng Guan Yunpeng Guan Xiaoyu Hou Xiaoyu Hou Peipei Tian Luping Ren Yong Tang An Song Jiajun Zhao Ling Gao Guangyao Song Guangyao Song Elevated Levels of Apolipoprotein CIII Increase the Risk of Postprandial Hypertriglyceridemia Frontiers in Endocrinology triglycerides dyslipidemia postprandial hypertriglyceridemia triglyceride-rich lipoprotein remnants apolipoprotein CIII |
author_facet |
Yunpeng Guan Yunpeng Guan Xiaoyu Hou Xiaoyu Hou Peipei Tian Luping Ren Yong Tang An Song Jiajun Zhao Ling Gao Guangyao Song Guangyao Song |
author_sort |
Yunpeng Guan |
title |
Elevated Levels of Apolipoprotein CIII Increase the Risk of Postprandial Hypertriglyceridemia |
title_short |
Elevated Levels of Apolipoprotein CIII Increase the Risk of Postprandial Hypertriglyceridemia |
title_full |
Elevated Levels of Apolipoprotein CIII Increase the Risk of Postprandial Hypertriglyceridemia |
title_fullStr |
Elevated Levels of Apolipoprotein CIII Increase the Risk of Postprandial Hypertriglyceridemia |
title_full_unstemmed |
Elevated Levels of Apolipoprotein CIII Increase the Risk of Postprandial Hypertriglyceridemia |
title_sort |
elevated levels of apolipoprotein ciii increase the risk of postprandial hypertriglyceridemia |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2021-04-01 |
description |
BackgroundTo investigate possible mechanisms of postprandial hypertriglyceridemia (PPT), we analyzed serum lipid and apolipoprotein (Apo) AI, B, CII and CIII levels before and after a high-fat meal.MethodsThe study has been registered with the China Clinical Trial Registry (registration number:ChiCTR1800019514; URL: http://www.chictr.org.cn/index.aspx). We recruited 143 volunteers with normal fasting triglyceride (TG) levels. All subjects consumed a high-fat test meal. Venous blood samples were obtained during fasting and at 2, 4, and 6 hours after the high-fat meal. PPT was defined as TG ≥2.5 mmol/L any time after the meal. Subjects were divided into two groups according to the high-fat meal test results: postprandial normal triglyceride (PNT) and PPT. We compared the fasting and postprandial lipid and ApoAI, ApoB, ApoCII and ApoCIII levels between the two groups.ResultsSignificant differences were found between the groups in fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), TG, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), TG-rich lipoprotein remnants (TRLRs), ApoB, ApoCIII, ApoAI/ApoB and ApoCII/ApoCIII. The insulin, HOMA-IR, TG, TC, LDL-C, non-HDL-C, TRLRs, ApoB, ApoCIII and ApoCII/ApoCIII values were higher in the PPT group, while the ApoAI/ApoB ratio was higher in the PNT group. The postprandial TG level peaked in the PNT group 2 hours after the meal but was significantly higher in the PPT group and peaked at 4 hours. TRLRs gradually increased within 6 hours after the high-fat meal in both groups. The area under the curve (AUC) of TG and TRLRs and the AUC increment were higher in the PPT group (P < 0.001). ApoCIII peaked in the PNT group 2 hours after the meal and gradually decreased. ApoCIII gradually increased in the PPT group within 6 hours after the meal, exhibiting a greater AUC increment (P < 0.001). Fasting ApoCIII was positively correlated with age, systolic and diastolic blood pressure, body mass index (BMI), waist circumference, TC, TG, LDL-C, non-HDL-C, TRLRs, and ApoB (P<0.05). ApoCIII was an independent risk factor of PPT after adjustment for BMI, waist circumference, TC, LDL-C, and ApoB (P < 0.001, OR=1.188).ConclusionsElevated ApoCIII levels may cause PPT. |
topic |
triglycerides dyslipidemia postprandial hypertriglyceridemia triglyceride-rich lipoprotein remnants apolipoprotein CIII |
url |
https://www.frontiersin.org/articles/10.3389/fendo.2021.646185/full |
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