A Quality Control Assay to Access the HCl Molarity of Radionuclide Solutions

A Quality Control Assay to Access the HCl Molarity of Radionuclide Solutions

Strontium-82 is produced by proton activation of a rubidium chloride target in an accelerator or cyclotron and purified by ion exchange chromatography. The Strontrium-82 is used in Cardigen generators to produce Rubidium-82 for cardiac imaging. Quality control testing of the purified Strontium-82 is...

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Bibliographic Details
Main Author: Jonathan Fitzsimmons
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Chemosensors
Subjects:
molarity test
quality control
strontium-82
Sr-82
BromoCresol Purple
Online Access:http://www.mdpi.com/2227-9040/4/2/9
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spelling doaj-e26ab9ed7c3b45a2a15cac9886868fc22020-11-24T22:51:21ZengMDPI AGChemosensors2227-90402016-05-0142910.3390/chemosensors4020009chemosensors4020009A Quality Control Assay to Access the HCl Molarity of Radionuclide SolutionsJonathan Fitzsimmons0Collider Accelerator Department, Brookhaven National Laboratory, Upton, NY 11973, USAStrontium-82 is produced by proton activation of a rubidium chloride target in an accelerator or cyclotron and purified by ion exchange chromatography. The Strontrium-82 is used in Cardigen generators to produce Rubidium-82 for cardiac imaging. Quality control testing of the purified Strontium-82 is performed with Inductively Coupled Plasma-Optical Emission spectroscopy (ICP-OES) and gamma spectroscopy. To meet Department of Energy specifications for HCl molarity the purified Strontium-82 solution needs to be tested to determine if the isotope is in the 0.05–0.5 M HCl range. This manuscript reports a simple HCl molarity test to determine if the purified Strontium-82 solution meets specifications. Validation of the assay was performed by evaluating all solutions associate with Strontium-82 processing.http://www.mdpi.com/2227-9040/4/2/9molarity testquality controlstrontium-82Sr-82BromoCresol Purple
collection DOAJ
language English
format Article
sources DOAJ
author Jonathan Fitzsimmons
spellingShingle Jonathan Fitzsimmons
A Quality Control Assay to Access the HCl Molarity of Radionuclide Solutions
Chemosensors
molarity test
quality control
strontium-82
Sr-82
BromoCresol Purple
author_facet Jonathan Fitzsimmons
author_sort Jonathan Fitzsimmons
title A Quality Control Assay to Access the HCl Molarity of Radionuclide Solutions
title_short A Quality Control Assay to Access the HCl Molarity of Radionuclide Solutions
title_full A Quality Control Assay to Access the HCl Molarity of Radionuclide Solutions
title_fullStr A Quality Control Assay to Access the HCl Molarity of Radionuclide Solutions
title_full_unstemmed A Quality Control Assay to Access the HCl Molarity of Radionuclide Solutions
title_sort quality control assay to access the hcl molarity of radionuclide solutions
publisher MDPI AG
series Chemosensors
issn 2227-9040
publishDate 2016-05-01
description Strontium-82 is produced by proton activation of a rubidium chloride target in an accelerator or cyclotron and purified by ion exchange chromatography. The Strontrium-82 is used in Cardigen generators to produce Rubidium-82 for cardiac imaging. Quality control testing of the purified Strontium-82 is performed with Inductively Coupled Plasma-Optical Emission spectroscopy (ICP-OES) and gamma spectroscopy. To meet Department of Energy specifications for HCl molarity the purified Strontium-82 solution needs to be tested to determine if the isotope is in the 0.05–0.5 M HCl range. This manuscript reports a simple HCl molarity test to determine if the purified Strontium-82 solution meets specifications. Validation of the assay was performed by evaluating all solutions associate with Strontium-82 processing.
topic molarity test
quality control
strontium-82
Sr-82
BromoCresol Purple
url http://www.mdpi.com/2227-9040/4/2/9
work_keys_str_mv AT jonathanfitzsimmons aqualitycontrolassaytoaccessthehclmolarityofradionuclidesolutions
AT jonathanfitzsimmons qualitycontrolassaytoaccessthehclmolarityofradionuclidesolutions
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