Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis.
Antibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function of B cells in human schistosomiasis. We set out to characterize B cell subsets and B cell responses to B cell receptor and Toll-like receptor 9 stimulat...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS Neglected Tropical Diseases |
Online Access: | http://europepmc.org/articles/PMC3591311?pdf=render |
id |
doaj-e26e231d4abc4bf8bed255d11d2108f4 |
---|---|
record_format |
Article |
spelling |
doaj-e26e231d4abc4bf8bed255d11d2108f42020-11-25T00:04:46ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27352013-01-0173e209410.1371/journal.pntd.0002094Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis.Lucja A LabudaUlysse Ateba-NgoaEliane Ngoune FeugapJorn J HeeringaLuciën E P M van der VlugtRegina B A PiresLudovic MewonoPeter G KremsnerMenno C van ZelmAyola A AdegnikaMaria YazdanbakhshHermelijn H SmitsAntibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function of B cells in human schistosomiasis. We set out to characterize B cell subsets and B cell responses to B cell receptor and Toll-like receptor 9 stimulation in Gabonese schoolchildren with Schistosoma haematobium infection. Frequencies of memory B cell (MBC) subsets were increased, whereas naive B cell frequencies were reduced in the schistosome-infected group. At the functional level, isolated B cells from schistosome-infected children showed higher expression of the activation marker CD23 upon stimulation, but lower proliferation and TNF-α production. Importantly, 6-months after 3 rounds of praziquantel treatment, frequencies of naive B cells were increased, MBC frequencies were decreased and with the exception of TNF-α production, B cell responsiveness was restored to what was seen in uninfected children. These data show that S. haematobium infection leads to significant changes in the B cell compartment, both at the phenotypic and functional level.http://europepmc.org/articles/PMC3591311?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lucja A Labuda Ulysse Ateba-Ngoa Eliane Ngoune Feugap Jorn J Heeringa Luciën E P M van der Vlugt Regina B A Pires Ludovic Mewono Peter G Kremsner Menno C van Zelm Ayola A Adegnika Maria Yazdanbakhsh Hermelijn H Smits |
spellingShingle |
Lucja A Labuda Ulysse Ateba-Ngoa Eliane Ngoune Feugap Jorn J Heeringa Luciën E P M van der Vlugt Regina B A Pires Ludovic Mewono Peter G Kremsner Menno C van Zelm Ayola A Adegnika Maria Yazdanbakhsh Hermelijn H Smits Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. PLoS Neglected Tropical Diseases |
author_facet |
Lucja A Labuda Ulysse Ateba-Ngoa Eliane Ngoune Feugap Jorn J Heeringa Luciën E P M van der Vlugt Regina B A Pires Ludovic Mewono Peter G Kremsner Menno C van Zelm Ayola A Adegnika Maria Yazdanbakhsh Hermelijn H Smits |
author_sort |
Lucja A Labuda |
title |
Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
title_short |
Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
title_full |
Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
title_fullStr |
Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
title_full_unstemmed |
Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
title_sort |
alterations in peripheral blood b cell subsets and dynamics of b cell responses during human schistosomiasis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Neglected Tropical Diseases |
issn |
1935-2735 |
publishDate |
2013-01-01 |
description |
Antibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function of B cells in human schistosomiasis. We set out to characterize B cell subsets and B cell responses to B cell receptor and Toll-like receptor 9 stimulation in Gabonese schoolchildren with Schistosoma haematobium infection. Frequencies of memory B cell (MBC) subsets were increased, whereas naive B cell frequencies were reduced in the schistosome-infected group. At the functional level, isolated B cells from schistosome-infected children showed higher expression of the activation marker CD23 upon stimulation, but lower proliferation and TNF-α production. Importantly, 6-months after 3 rounds of praziquantel treatment, frequencies of naive B cells were increased, MBC frequencies were decreased and with the exception of TNF-α production, B cell responsiveness was restored to what was seen in uninfected children. These data show that S. haematobium infection leads to significant changes in the B cell compartment, both at the phenotypic and functional level. |
url |
http://europepmc.org/articles/PMC3591311?pdf=render |
work_keys_str_mv |
AT lucjaalabuda alterationsinperipheralbloodbcellsubsetsanddynamicsofbcellresponsesduringhumanschistosomiasis AT ulysseatebangoa alterationsinperipheralbloodbcellsubsetsanddynamicsofbcellresponsesduringhumanschistosomiasis AT elianengounefeugap alterationsinperipheralbloodbcellsubsetsanddynamicsofbcellresponsesduringhumanschistosomiasis AT jornjheeringa alterationsinperipheralbloodbcellsubsetsanddynamicsofbcellresponsesduringhumanschistosomiasis AT lucienepmvandervlugt alterationsinperipheralbloodbcellsubsetsanddynamicsofbcellresponsesduringhumanschistosomiasis AT reginabapires alterationsinperipheralbloodbcellsubsetsanddynamicsofbcellresponsesduringhumanschistosomiasis AT ludovicmewono alterationsinperipheralbloodbcellsubsetsanddynamicsofbcellresponsesduringhumanschistosomiasis AT petergkremsner alterationsinperipheralbloodbcellsubsetsanddynamicsofbcellresponsesduringhumanschistosomiasis AT mennocvanzelm alterationsinperipheralbloodbcellsubsetsanddynamicsofbcellresponsesduringhumanschistosomiasis AT ayolaaadegnika alterationsinperipheralbloodbcellsubsetsanddynamicsofbcellresponsesduringhumanschistosomiasis AT mariayazdanbakhsh alterationsinperipheralbloodbcellsubsetsanddynamicsofbcellresponsesduringhumanschistosomiasis AT hermelijnhsmits alterationsinperipheralbloodbcellsubsetsanddynamicsofbcellresponsesduringhumanschistosomiasis |
_version_ |
1725428080427663360 |