Stability and Influence of Storage Conditions on Nanofibrous Film Containing Tooth Whitening Agent
Carbamide peroxide (CP), a tooth whitening agent, is chemically unstable. The present study explores stability enhancement of CP by loading in a nanofibrous film (CP-F) composed of polyvinyl alcohol/polyvinylpyrrolidone/silica mixture, using an electrospinning technique. Kept at a temperature range...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-03-01
|
Series: | Pharmaceutics |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4923/13/4/449 |
id |
doaj-e271926dc9014debaf80c215520e89af |
---|---|
record_format |
Article |
spelling |
doaj-e271926dc9014debaf80c215520e89af2021-03-27T00:05:17ZengMDPI AGPharmaceutics1999-49232021-03-011344944910.3390/pharmaceutics13040449Stability and Influence of Storage Conditions on Nanofibrous Film Containing Tooth Whitening AgentSiriporn Okonogi0Adchareeya Kaewpinta1Pisaisit Chaijareenont2Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandInterdisciplinary Program in Nanoscience and Nanotechnology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, ThailandResearch Center of Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai 50200, ThailandCarbamide peroxide (CP), a tooth whitening agent, is chemically unstable. The present study explores stability enhancement of CP by loading in a nanofibrous film (CP-F) composed of polyvinyl alcohol/polyvinylpyrrolidone/silica mixture, using an electrospinning technique. Kept at a temperature range of 60–80 °C for 6 h, CP in CP-F showed significantly higher stability than that in a polymer solution and in water, respectively. Degradation of CP in CP-F could be described by the first order kinetics with the predicted half-life by the Arrhenius equation of approximately 6.52 years. Physicochemical properties of CP-F after long-term storage for 12 months at different temperatures and relative humidity (RH) were investigated using scanning electron microscopy, X-ray diffractometry, differential scanning calorimetry, and Fourier transform infrared spectroscopy. It was found that high temperature and high humidity (45 °C/75% RH) could enhance water absorption and destruction of the nanofibrous structure of CP-F. Interestingly, kept at 25 °C/30% RH, the nanofibrous structure of CP-F was not damaged, and exhibited no water absorption. Moreover, the remaining CP, the mechanical properties, and the adhesive properties of CP-F were not significantly changed in this storage condition. It is concluded that the developed CP-F and a suitable storage condition can significantly improve CP stability.https://www.mdpi.com/1999-4923/13/4/449carbamide peroxidenanofibrous filmstabilitystability kineticsphysicochemical propertiesstorage |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Siriporn Okonogi Adchareeya Kaewpinta Pisaisit Chaijareenont |
spellingShingle |
Siriporn Okonogi Adchareeya Kaewpinta Pisaisit Chaijareenont Stability and Influence of Storage Conditions on Nanofibrous Film Containing Tooth Whitening Agent Pharmaceutics carbamide peroxide nanofibrous film stability stability kinetics physicochemical properties storage |
author_facet |
Siriporn Okonogi Adchareeya Kaewpinta Pisaisit Chaijareenont |
author_sort |
Siriporn Okonogi |
title |
Stability and Influence of Storage Conditions on Nanofibrous Film Containing Tooth Whitening Agent |
title_short |
Stability and Influence of Storage Conditions on Nanofibrous Film Containing Tooth Whitening Agent |
title_full |
Stability and Influence of Storage Conditions on Nanofibrous Film Containing Tooth Whitening Agent |
title_fullStr |
Stability and Influence of Storage Conditions on Nanofibrous Film Containing Tooth Whitening Agent |
title_full_unstemmed |
Stability and Influence of Storage Conditions on Nanofibrous Film Containing Tooth Whitening Agent |
title_sort |
stability and influence of storage conditions on nanofibrous film containing tooth whitening agent |
publisher |
MDPI AG |
series |
Pharmaceutics |
issn |
1999-4923 |
publishDate |
2021-03-01 |
description |
Carbamide peroxide (CP), a tooth whitening agent, is chemically unstable. The present study explores stability enhancement of CP by loading in a nanofibrous film (CP-F) composed of polyvinyl alcohol/polyvinylpyrrolidone/silica mixture, using an electrospinning technique. Kept at a temperature range of 60–80 °C for 6 h, CP in CP-F showed significantly higher stability than that in a polymer solution and in water, respectively. Degradation of CP in CP-F could be described by the first order kinetics with the predicted half-life by the Arrhenius equation of approximately 6.52 years. Physicochemical properties of CP-F after long-term storage for 12 months at different temperatures and relative humidity (RH) were investigated using scanning electron microscopy, X-ray diffractometry, differential scanning calorimetry, and Fourier transform infrared spectroscopy. It was found that high temperature and high humidity (45 °C/75% RH) could enhance water absorption and destruction of the nanofibrous structure of CP-F. Interestingly, kept at 25 °C/30% RH, the nanofibrous structure of CP-F was not damaged, and exhibited no water absorption. Moreover, the remaining CP, the mechanical properties, and the adhesive properties of CP-F were not significantly changed in this storage condition. It is concluded that the developed CP-F and a suitable storage condition can significantly improve CP stability. |
topic |
carbamide peroxide nanofibrous film stability stability kinetics physicochemical properties storage |
url |
https://www.mdpi.com/1999-4923/13/4/449 |
work_keys_str_mv |
AT siripornokonogi stabilityandinfluenceofstorageconditionsonnanofibrousfilmcontainingtoothwhiteningagent AT adchareeyakaewpinta stabilityandinfluenceofstorageconditionsonnanofibrousfilmcontainingtoothwhiteningagent AT pisaisitchaijareenont stabilityandinfluenceofstorageconditionsonnanofibrousfilmcontainingtoothwhiteningagent |
_version_ |
1724201648834740224 |