An Update on Neurofibromatosis Type 1-Associated Gliomas

Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome that affects children and adults. Individuals with NF1 are at high risk for central nervous system neoplasms including gliomas. The purpose of this review is to discuss the spectrum of intracranial gliomas arising...

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Main Authors:	Mina Lobbous, Joshua D. Bernstock, Elizabeth Coffee, Gregory K. Friedman, Laura K Metrock, Gustavo Chagoya, Galal Elsayed, Ichiro Nakano, James R. Hackney, Bruce R. Korf, Louis B. Nabors
Format:	Article
Language:	English
Published:	MDPI AG 2020-01-01
Series:	Cancers
Subjects:	neurofibromatosis gliomas glioblastoma therapeutics astrocytoma
Online Access:	https://www.mdpi.com/2072-6694/12/1/114

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spelling	doaj-e27936e94c584b2e87c97ae1e555cdac2020-11-25T01:38:06ZengMDPI AGCancers2072-66942020-01-0112111410.3390/cancers12010114cancers12010114An Update on Neurofibromatosis Type 1-Associated GliomasMina Lobbous0Joshua D. Bernstock1Elizabeth Coffee2Gregory K. Friedman3Laura K Metrock4Gustavo Chagoya5Galal Elsayed6Ichiro Nakano7James R. Hackney8Bruce R. Korf9Louis B. Nabors10Division of Neuro Oncology, Department of Neurology, University of Alabama at Birmingham, 510 20th Street South, Faculty Office Tower suite 1020 Birmingham, Birmingham, AL 35294, USADepartment of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADivision of Neuro Oncology, Department of Neurology, University of Alabama at Birmingham, 510 20th Street South, Faculty Office Tower suite 1020 Birmingham, Birmingham, AL 35294, USADivision of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USADivision of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USADivision of Neuro Oncology, Department of Neurology, University of Alabama at Birmingham, 510 20th Street South, Faculty Office Tower suite 1020 Birmingham, Birmingham, AL 35294, USANeurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome that affects children and adults. Individuals with NF1 are at high risk for central nervous system neoplasms including gliomas. The purpose of this review is to discuss the spectrum of intracranial gliomas arising in individuals with NF1 with a focus on recent preclinical and clinical data. In this review, possible mechanisms of gliomagenesis are discussed, including the contribution of different signaling pathways and tumor microenvironment. Furthermore, we discuss the recent notable advances in the developing therapeutic landscape for NF1-associated gliomas including clinical trials and collaborative efforts.https://www.mdpi.com/2072-6694/12/1/114neurofibromatosisgliomasglioblastomatherapeuticsastrocytoma
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mina Lobbous Joshua D. Bernstock Elizabeth Coffee Gregory K. Friedman Laura K Metrock Gustavo Chagoya Galal Elsayed Ichiro Nakano James R. Hackney Bruce R. Korf Louis B. Nabors
spellingShingle	Mina Lobbous Joshua D. Bernstock Elizabeth Coffee Gregory K. Friedman Laura K Metrock Gustavo Chagoya Galal Elsayed Ichiro Nakano James R. Hackney Bruce R. Korf Louis B. Nabors An Update on Neurofibromatosis Type 1-Associated Gliomas Cancers neurofibromatosis gliomas glioblastoma therapeutics astrocytoma
author_facet	Mina Lobbous Joshua D. Bernstock Elizabeth Coffee Gregory K. Friedman Laura K Metrock Gustavo Chagoya Galal Elsayed Ichiro Nakano James R. Hackney Bruce R. Korf Louis B. Nabors
author_sort	Mina Lobbous
title	An Update on Neurofibromatosis Type 1-Associated Gliomas
title_short	An Update on Neurofibromatosis Type 1-Associated Gliomas
title_full	An Update on Neurofibromatosis Type 1-Associated Gliomas
title_fullStr	An Update on Neurofibromatosis Type 1-Associated Gliomas
title_full_unstemmed	An Update on Neurofibromatosis Type 1-Associated Gliomas
title_sort	update on neurofibromatosis type 1-associated gliomas
publisher	MDPI AG
series	Cancers
issn	2072-6694
publishDate	2020-01-01
description	Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome that affects children and adults. Individuals with NF1 are at high risk for central nervous system neoplasms including gliomas. The purpose of this review is to discuss the spectrum of intracranial gliomas arising in individuals with NF1 with a focus on recent preclinical and clinical data. In this review, possible mechanisms of gliomagenesis are discussed, including the contribution of different signaling pathways and tumor microenvironment. Furthermore, we discuss the recent notable advances in the developing therapeutic landscape for NF1-associated gliomas including clinical trials and collaborative efforts.
topic	neurofibromatosis gliomas glioblastoma therapeutics astrocytoma
url	https://www.mdpi.com/2072-6694/12/1/114
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An Update on Neurofibromatosis Type 1-Associated Gliomas

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