Assessment of anti-nociceptive efficacy of Costus Speciosus rhizome in swiss albino mice

• Main Authors: Sanjib Bhattacharya, Upendra Nagaich
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2010-01-01
• Series: Journal of Advanced Pharmaceutical Technology & Research
• Subjects: Costus speciosus; rhizome; writhing; tail flick
• Online Access: http://www.japtr.org/article.asp?issn=2231-4040;year=2010;volume=1;issue=1;spage=34;epage=40;aulast=Bhattacharya

Present study attempts to evaluate the anti-nociceptive activity of the aqueous and ethanol extracts of Costus speciosus rhizome (CPA and CPE) in Swiss albino mice. The maceration extracts were evaluated for anti-nociceptive activity by acetic acid-induced writhing and tail flick method in mice. The anti-nociceptive screening revealed significant peripheral anti-nociceptive actions of both extracts against acetic acid induced writhing in mice. Aqueous extract (CPA) significantly inhibited writhes at the dose of 75 and 150 mg/kg body weight, while ethanol extract (CPE) produced significant protection at the dose of 150 mg/kg body weight. However, in tail flick method only the ethanol extract (CPE) showed significant central analgesic action, while aqueous extract was totally ineffective. The present investigation demonstrates that the rhizome extracts of C. speciosus exhibited significant anti-nociceptive effects in Swiss albino mice.