Oxidative stress induced mitochondrial protein kinase A mediates cytochrome c oxidase dysfunction.
Previously we showed that Protein kinase A (PKA) activated in hypoxia and myocardial ischemia/reperfusion mediates phosphorylation of subunits I, IVi1 and Vb of cytochrome c oxidase. However, the mechanism of activation of the kinase under hypoxia remains unclear. It is also unclear if hypoxic stres...
Main Authors: | Satish Srinivasan, Joseph Spear, Karunakaran Chandran, Joy Joseph, Balaraman Kalyanaraman, Narayan G Avadhani |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3795003?pdf=render |
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