Association between Chronic Periodontitis and Serum Lipid Levels with its Risk to Atherosclerosis

• Main Authors: Kush Pathak, Madhusudan Ashtekar, Rashmi Metgud, Suruchi Tekade, Sandeep Jain, Satyajit Tekade
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2014-01-01
• Series: Advances in Human Biology
• Subjects: HDL Cholesterol; LDL Cholesterol; Triglycerides.
• Online Access: http://www.aihbonline.com/article.asp?issn=2321-8568;year=2014;volume=4;issue=3;spage=44;epage=47;aulast=Pathak;type=0

Aim: Regarding the high prevalence of hyperlpidaemia, which is one of the major risk fa ctors of cardiovascular disease and uncertain reports about the relation between periodontal disease and serum lipid profile, this study was conducted to assess the relation. Materials and Methods: The cohort study was conducted on 45 cases including 30 persons with chronic periodontitis as case group, and 15 healthy subjects as control group. Both groups had same age and weight ranges, sex and diet, without any periodontal treatment history in the past six months, underlying systemic disease such as diabetes, anti-hyperlipidemic drugs or active tobacco smoking history. Low density lipoprotein (LDL), High density lipoprotein (HDL), Triglyceride (TG) and total cholesterol levels (CHOL) were measured by direct enzymatic assay. Results: TG level was 116.713+/-30.485 mg/dl in control group and 166.197+/-69.332 in case group (P = <0.001). In control group, LDL was 90.347+/-21.565 and in case group, 105.813+/-19.197, which presents a significantly higher level (P=<0.01) in case group. Other serum level indices also showed highly significant difference between the two groups. Conclusion: The study along with other studies till date has provided evidence that periodontal disease has a causal link to atherosclerosis. Further research must be conducted to definitively establish the role of periodontal disease in the etiology of atherosclerosis.