PROPRIEDADES FARMACOCINÉTICAS E INTERAÇÃO DE HÍBRIDOS DE IBUPROFENO E PRODUTOS NATURAIS COM PROSTAGLANDINA G/H SINTASE 2
Ibuprofen, in addition to having beneficial properties, cause serious side effects, ranging from gastrointestinal ulcerations until bleeding. These unwanted effects stimulate the research & development of new and more effective therapeutic agents and less harmful to human health. In this con...
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doaj-e29f61a5ef7f4959a914b1f1121231b92020-11-25T02:49:53ZporUniversidade do Oeste PaulistaColloquium Exactarum2178-83322014-12-010604213010.5747/ce.2014.v06.n4.e096PROPRIEDADES FARMACOCINÉTICAS E INTERAÇÃO DE HÍBRIDOS DE IBUPROFENO E PRODUTOS NATURAIS COM PROSTAGLANDINA G/H SINTASE 2Adriano L. Romero0João Pedro de A. Souza1Rafaelle B. Romero2Universidade Tecnológica Federal do ParanáUniversidade Tecnológica Federal do ParanáUniversidade Tecnológica Federal do ParanáIbuprofen, in addition to having beneficial properties, cause serious side effects, ranging from gastrointestinal ulcerations until bleeding. These unwanted effects stimulate the research & development of new and more effective therapeutic agents and less harmful to human health. In this context, the aim of this study was to conduct an in silico study to evaluate pharmacokinetics properties, toxic effects and interaction of ibuprofenates derived from natural products with prostaglandin G/H synthase 2. The anisyl, thymil and eugenyl ibuprofenates showed molecular properties and low or no toxicity, expected for bioactive substances with potential drug candidates. Furthermore, it was observed that the ibuprofenates evaluated had higher interaction energy with the prostaglandin G/H synthase 2 in a similar orientation to ibuprofen drug. http://revistas.unoeste.br/revistas/ojs/index.php/ce/article/view/1299/1402ibuprofendocking molecularprostaglandin G/H synthase 2 |
collection |
DOAJ |
language |
Portuguese |
format |
Article |
sources |
DOAJ |
author |
Adriano L. Romero João Pedro de A. Souza Rafaelle B. Romero |
spellingShingle |
Adriano L. Romero João Pedro de A. Souza Rafaelle B. Romero PROPRIEDADES FARMACOCINÉTICAS E INTERAÇÃO DE HÍBRIDOS DE IBUPROFENO E PRODUTOS NATURAIS COM PROSTAGLANDINA G/H SINTASE 2 Colloquium Exactarum ibuprofen docking molecular prostaglandin G/H synthase 2 |
author_facet |
Adriano L. Romero João Pedro de A. Souza Rafaelle B. Romero |
author_sort |
Adriano L. Romero |
title |
PROPRIEDADES FARMACOCINÉTICAS E INTERAÇÃO DE HÍBRIDOS DE IBUPROFENO E PRODUTOS NATURAIS COM PROSTAGLANDINA G/H SINTASE 2 |
title_short |
PROPRIEDADES FARMACOCINÉTICAS E INTERAÇÃO DE HÍBRIDOS DE IBUPROFENO E PRODUTOS NATURAIS COM PROSTAGLANDINA G/H SINTASE 2 |
title_full |
PROPRIEDADES FARMACOCINÉTICAS E INTERAÇÃO DE HÍBRIDOS DE IBUPROFENO E PRODUTOS NATURAIS COM PROSTAGLANDINA G/H SINTASE 2 |
title_fullStr |
PROPRIEDADES FARMACOCINÉTICAS E INTERAÇÃO DE HÍBRIDOS DE IBUPROFENO E PRODUTOS NATURAIS COM PROSTAGLANDINA G/H SINTASE 2 |
title_full_unstemmed |
PROPRIEDADES FARMACOCINÉTICAS E INTERAÇÃO DE HÍBRIDOS DE IBUPROFENO E PRODUTOS NATURAIS COM PROSTAGLANDINA G/H SINTASE 2 |
title_sort |
propriedades farmacocinéticas e interação de híbridos de ibuprofeno e produtos naturais com prostaglandina g/h sintase 2 |
publisher |
Universidade do Oeste Paulista |
series |
Colloquium Exactarum |
issn |
2178-8332 |
publishDate |
2014-12-01 |
description |
Ibuprofen, in addition to having beneficial properties,
cause serious side effects, ranging from gastrointestinal ulcerations
until bleeding. These unwanted effects stimulate the research &
development of new and more effective therapeutic agents and less
harmful to human health. In this context, the aim of this study was to
conduct an in silico study to evaluate pharmacokinetics properties,
toxic effects and interaction of ibuprofenates derived from natural
products with prostaglandin G/H synthase 2. The anisyl, thymil and
eugenyl ibuprofenates showed molecular properties and low or no
toxicity, expected for bioactive substances with potential drug
candidates. Furthermore, it was observed that the ibuprofenates
evaluated had higher interaction energy with the prostaglandin G/H
synthase 2 in a similar orientation to ibuprofen drug.
|
topic |
ibuprofen docking molecular prostaglandin G/H synthase 2 |
url |
http://revistas.unoeste.br/revistas/ojs/index.php/ce/article/view/1299/1402 |
work_keys_str_mv |
AT adrianolromero propriedadesfarmacocineticaseinteracaodehibridosdeibuprofenoeprodutosnaturaiscomprostaglandinaghsintase2 AT joaopedrodeasouza propriedadesfarmacocineticaseinteracaodehibridosdeibuprofenoeprodutosnaturaiscomprostaglandinaghsintase2 AT rafaellebromero propriedadesfarmacocineticaseinteracaodehibridosdeibuprofenoeprodutosnaturaiscomprostaglandinaghsintase2 |
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1724741553998528512 |