Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro.
AIM OF THE STUDY:To evaluate the frequency of MRE11/RAD50/NBS1 (MRN)-complex loss of protein expression in endometrial cancers (EC) and to determine whether loss of MRE11 renders the cancer cells sensitive to Poly(ADP-ribose) polymerase (PARP)-inhibitory treatment. METHODS:MRN expression was examine...
Main Authors: | Romana Koppensteiner, Eleftherios P Samartzis, Aurelia Noske, Adriana von Teichman, Ioannis Dedes, Myriam Gwerder, Patrick Imesch, Kristian Ikenberg, Holger Moch, Daniel Fink, Manuel Stucki, Konstantin J Dedes |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4057395?pdf=render |
Similar Items
-
ARID1A Mutations and PI3K/AKT Pathway Alterations in Endometriosis and Endometriosis-Associated Ovarian Carcinomas
by: Patrick Imesch, et al.
Published: (2013-09-01) -
Expression of the G protein-coupled estrogen receptor (GPER) in endometriosis: a tissue microarray study
by: Samartzis Nicolas, et al.
Published: (2012-04-01) -
Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: a tissue microarray study
by: Samartzis Nicolas, et al.
Published: (2011-10-01) -
Doxycycline reduces MMP-2 activity and inhibits invasion of 12Z epithelial endometriotic cells as well as MMP-2 and -9 activity in primary endometriotic stromal cells in vitro
by: Eleftherios P. Samartzis, et al.
Published: (2019-04-01) -
The G protein-coupled estrogen receptor (GPER) is expressed in two different subcellular localizations reflecting distinct tumor properties in breast cancer.
by: Eleftherios P Samartzis, et al.
Published: (2014-01-01)