SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation

SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation

SIRT2, a member of the sirtuin family, has been recently shown to exert important effects on mitosis and/or metabolism. However, its roles in oocyte maturation have not been fully clarified. In this study, SIRT2, located in the cytoplasm and nucleus, was found in abundance in the meiotic stage, and...

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Bibliographic Details
Main Authors: Dejun Xu, Lin Wu, Xiaohan Jiang, Li Yang, Jianyong Cheng, Huali Chen, Rongmao Hua, Guoxia Geng, Lulu Yang, Qingwang Li
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
SIRT2
oocyte maturation
meiosis
mitochondria
acetylation
Online Access:http://www.mdpi.com/1422-0067/20/6/1365

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http://www.mdpi.com/1422-0067/20/6/1365

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