Serious Drug-Drug Interactions in the Prescriptions of Diabetic Patients
A large number of drugs are introduced every year, and newer interactions between medications are increasingly reported. Clinically significant drug interactions can occur when two or more drugs are taken in combination. With the continuing increase in the list of drugs capable of interactions, dete...
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doaj-e2d45e8095a94e7fbf0112adfdf236cc2020-11-24T21:34:41ZengMDPI AGMedical Sciences2076-32712015-10-01349310310.3390/medsci3040093medsci3040093Serious Drug-Drug Interactions in the Prescriptions of Diabetic PatientsVeintramuthu Sankar0Yousif Saaed1Rinku Mary Joseph2Hudson Azizi3Pinky Mariyam Thomas4Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore, Tamilnadu-641004, IndiaDepartment of Pharmaceutics, PSG College of Pharmacy, Coimbatore, Tamilnadu-641004, IndiaDepartment of Pharmaceutics, PSG College of Pharmacy, Coimbatore, Tamilnadu-641004, IndiaDepartment of Pharmaceutics, PSG College of Pharmacy, Coimbatore, Tamilnadu-641004, IndiaDepartment of Pharmaceutics, PSG College of Pharmacy, Coimbatore, Tamilnadu-641004, IndiaA large number of drugs are introduced every year, and newer interactions between medications are increasingly reported. Clinically significant drug interactions can occur when two or more drugs are taken in combination. With the continuing increase in the list of drugs capable of interactions, detection of these interactions from prescriptions becomes more important to ensure effective patient care. The aim of this study is to identify the possible drug interactions in the prescriptions of diabetic inpatients and to make physicians aware of these interactions to prevent the occurrence of clinically adverse effects. In a specially designed and validated data entry format, data for the following criteria were collected: drugs prescribed, major drug class prescribed, pharmacological classification of the observed drug interaction, and frequently occurring drug interactions. All the possible drug interactions were identified and evaluated using standard drug interaction reference books and databases. During the study period, 50 prescriptions of diabetic inpatients were screened randomly. Out of these prescriptions, 35 (70%) prescriptions had at least one possible drug-drug interaction. The major classes of drugs causing interactions included cardiac drugs (92%), analgesic drugs (66%), antibiotic drugs (52%), antidiabetic drugs (26%), diuretic drugs (26%), and antipsychotic drugs (24%). This study showed that 34 (68%) of the above prescriptions had minor interactions, 33(66%) had moderate interactions, and 10 (20%) had severe interactions. Of these, the drugs prescribed specifically for diabetes caused only nine moderate interactions. Thus, screening of prescriptions by the clinical pharmacist will help to minimize clinical occurrence of major/severe drug interactions in diabetic patients.http://www.mdpi.com/2076-3271/3/4/93diabetes mellitusdrug interactionsidentificationprescriptions |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Veintramuthu Sankar Yousif Saaed Rinku Mary Joseph Hudson Azizi Pinky Mariyam Thomas |
spellingShingle |
Veintramuthu Sankar Yousif Saaed Rinku Mary Joseph Hudson Azizi Pinky Mariyam Thomas Serious Drug-Drug Interactions in the Prescriptions of Diabetic Patients Medical Sciences diabetes mellitus drug interactions identification prescriptions |
author_facet |
Veintramuthu Sankar Yousif Saaed Rinku Mary Joseph Hudson Azizi Pinky Mariyam Thomas |
author_sort |
Veintramuthu Sankar |
title |
Serious Drug-Drug Interactions in the Prescriptions of Diabetic Patients |
title_short |
Serious Drug-Drug Interactions in the Prescriptions of Diabetic Patients |
title_full |
Serious Drug-Drug Interactions in the Prescriptions of Diabetic Patients |
title_fullStr |
Serious Drug-Drug Interactions in the Prescriptions of Diabetic Patients |
title_full_unstemmed |
Serious Drug-Drug Interactions in the Prescriptions of Diabetic Patients |
title_sort |
serious drug-drug interactions in the prescriptions of diabetic patients |
publisher |
MDPI AG |
series |
Medical Sciences |
issn |
2076-3271 |
publishDate |
2015-10-01 |
description |
A large number of drugs are introduced every year, and newer interactions between medications are increasingly reported. Clinically significant drug interactions can occur when two or more drugs are taken in combination. With the continuing increase in the list of drugs capable of interactions, detection of these interactions from prescriptions becomes more important to ensure effective patient care. The aim of this study is to identify the possible drug interactions in the prescriptions of diabetic inpatients and to make physicians aware of these interactions to prevent the occurrence of clinically adverse effects. In a specially designed and validated data entry format, data for the following criteria were collected: drugs prescribed, major drug class prescribed, pharmacological classification of the observed drug interaction, and frequently occurring drug interactions. All the possible drug interactions were identified and evaluated using standard drug interaction reference books and databases. During the study period, 50 prescriptions of diabetic inpatients were screened randomly. Out of these prescriptions, 35 (70%) prescriptions had at least one possible drug-drug interaction. The major classes of drugs causing interactions included cardiac drugs (92%), analgesic drugs (66%), antibiotic drugs (52%), antidiabetic drugs (26%), diuretic drugs (26%), and antipsychotic drugs (24%). This study showed that 34 (68%) of the above prescriptions had minor interactions, 33(66%) had moderate interactions, and 10 (20%) had severe interactions. Of these, the drugs prescribed specifically for diabetes caused only nine moderate interactions. Thus, screening of prescriptions by the clinical pharmacist will help to minimize clinical occurrence of major/severe drug interactions in diabetic patients. |
topic |
diabetes mellitus drug interactions identification prescriptions |
url |
http://www.mdpi.com/2076-3271/3/4/93 |
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