Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using small-molecular-weight paracellular markers

Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using small-molecular-weight paracellular markers

Abstract Background The blood–brain barrier (BBB) plays a critical role in protecting the central nervous system (CNS) from blood-borne agents and potentially harmful xenobiotics. Our group’s previous data has shown that tobacco smoke (TS) and electronic cigarettes (EC) affect the BBB integrity, inc...

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Bibliographic Details
Main Authors: Hossam Kadry, Behnam Noorani, Ulrich Bickel, Thomas J. Abbruscato, Luca Cucullo
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Fluids and Barriers of the CNS
Subjects:
Tobacco smoke
Electronic cigarettes
JUUL
Permeability markers
Sucrose
BBB
Online Access:https://doi.org/10.1186/s12987-021-00261-4

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