Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using small-molecular-weight paracellular markers
Abstract Background The blood–brain barrier (BBB) plays a critical role in protecting the central nervous system (CNS) from blood-borne agents and potentially harmful xenobiotics. Our group’s previous data has shown that tobacco smoke (TS) and electronic cigarettes (EC) affect the BBB integrity, inc...
Main Authors: | Hossam Kadry, Behnam Noorani, Ulrich Bickel, Thomas J. Abbruscato, Luca Cucullo |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-06-01
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Series: | Fluids and Barriers of the CNS |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12987-021-00261-4 |
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