Zopfiellasins A–D, Two Pairs of Epimeric Cytochalasins from Kiwi-Associated Fungus <i>Zopfiella</i> sp. and Their Antibacterial Assessment

Zopfiellasins A–D, Two Pairs of Epimeric Cytochalasins from Kiwi-Associated Fungus <i>Zopfiella</i> sp. and Their Antibacterial Assessment

In our continuous search for antibacterial agents against <i>Pseudomonas syringae</i> pv. <i>actinidiae</i> (Psa) from kiwi-associated fungi, two pairs of epimeric cytochalasins, zopfiellasins A–D (<b>1</b>–<b>4</b>), were characterized from the fungus...

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Main Authors: Jie-Yu Zhang, Juan He, Zheng-Hui Li, Tao Feng, Ji-Kai Liu
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
<i>Zopfiella</i> sp.
cytochalasins
<i>Pseudomonas syringae</i> pv. <i>actinidiae</i>
antibacterial
Online Access:https://www.mdpi.com/1420-3049/26/18/5611
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spelling doaj-e2d8b0b6e84f4dcd96ddaa6484ff09da2021-09-26T00:46:42ZengMDPI AGMolecules1420-30492021-09-01265611561110.3390/molecules26185611Zopfiellasins A–D, Two Pairs of Epimeric Cytochalasins from Kiwi-Associated Fungus <i>Zopfiella</i> sp. and Their Antibacterial AssessmentJie-Yu Zhang0Juan He1Zheng-Hui Li2Tao Feng3Ji-Kai Liu4School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaIn our continuous search for antibacterial agents against <i>Pseudomonas syringae</i> pv. <i>actinidiae</i> (Psa) from kiwi-associated fungi, two pairs of epimeric cytochalasins, zopfiellasins A–D (<b>1</b>–<b>4</b>), were characterized from the fungus <i>Zopfiella</i> sp. The structures were established on the basis of spectroscopic data analysis, while the absolute configurations were determined by single-crystal X-ray diffraction. Compounds <b>1</b> and <b>3</b> exhibited antibacterial activity against Psa with MIC values of 25 and 50 μg/mL, respectively. This is the first report of anti-Psa activity of cytochalasin derivatives.https://www.mdpi.com/1420-3049/26/18/5611<i>Zopfiella</i> sp.cytochalasins<i>Pseudomonas syringae</i> pv. <i>actinidiae</i>antibacterial
collection DOAJ
language English
format Article
sources DOAJ
author Jie-Yu Zhang
Juan He
Zheng-Hui Li
Tao Feng
Ji-Kai Liu
spellingShingle Jie-Yu Zhang
Juan He
Zheng-Hui Li
Tao Feng
Ji-Kai Liu
Zopfiellasins A–D, Two Pairs of Epimeric Cytochalasins from Kiwi-Associated Fungus <i>Zopfiella</i> sp. and Their Antibacterial Assessment
Molecules
<i>Zopfiella</i> sp.
cytochalasins
<i>Pseudomonas syringae</i> pv. <i>actinidiae</i>
antibacterial
author_facet Jie-Yu Zhang
Juan He
Zheng-Hui Li
Tao Feng
Ji-Kai Liu
author_sort Jie-Yu Zhang
title Zopfiellasins A–D, Two Pairs of Epimeric Cytochalasins from Kiwi-Associated Fungus <i>Zopfiella</i> sp. and Their Antibacterial Assessment
title_short Zopfiellasins A–D, Two Pairs of Epimeric Cytochalasins from Kiwi-Associated Fungus <i>Zopfiella</i> sp. and Their Antibacterial Assessment
title_full Zopfiellasins A–D, Two Pairs of Epimeric Cytochalasins from Kiwi-Associated Fungus <i>Zopfiella</i> sp. and Their Antibacterial Assessment
title_fullStr Zopfiellasins A–D, Two Pairs of Epimeric Cytochalasins from Kiwi-Associated Fungus <i>Zopfiella</i> sp. and Their Antibacterial Assessment
title_full_unstemmed Zopfiellasins A–D, Two Pairs of Epimeric Cytochalasins from Kiwi-Associated Fungus <i>Zopfiella</i> sp. and Their Antibacterial Assessment
title_sort zopfiellasins a–d, two pairs of epimeric cytochalasins from kiwi-associated fungus <i>zopfiella</i> sp. and their antibacterial assessment
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2021-09-01
description In our continuous search for antibacterial agents against <i>Pseudomonas syringae</i> pv. <i>actinidiae</i> (Psa) from kiwi-associated fungi, two pairs of epimeric cytochalasins, zopfiellasins A–D (<b>1</b>–<b>4</b>), were characterized from the fungus <i>Zopfiella</i> sp. The structures were established on the basis of spectroscopic data analysis, while the absolute configurations were determined by single-crystal X-ray diffraction. Compounds <b>1</b> and <b>3</b> exhibited antibacterial activity against Psa with MIC values of 25 and 50 μg/mL, respectively. This is the first report of anti-Psa activity of cytochalasin derivatives.
topic <i>Zopfiella</i> sp.
cytochalasins
<i>Pseudomonas syringae</i> pv. <i>actinidiae</i>
antibacterial
url https://www.mdpi.com/1420-3049/26/18/5611
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