Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study
Abstract Background Obsessive–compulsive disorder (OCD) is a complex disorder with 40%–60% of patients' refractory to treatment. Transcranial direct current stimulation (tDCS) has been shown to induce potent and long‐lasting effects on cortical excitability. The aim of the present clinical tria...
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doaj-e2dc0c6ac36440a5bd6457d69fc933042020-11-25T03:22:47ZengWileyBrain and Behavior2162-32792020-07-01107n/an/a10.1002/brb3.1648Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label studyGhina Harika‐Germaneau0Damien Heit1Armand Chatard2Berangere Thirioux3Nicolas Langbour4Nemat Jaafari5Unité de Recherché Clinique Intersectorielle en Psychiatrie à vocation régionale Centre Hospitalier Henri Laborit Poitiers FranceUnité de Recherché Clinique Intersectorielle en Psychiatrie à vocation régionale Centre Hospitalier Henri Laborit Poitiers FranceUnité de Recherché Clinique Intersectorielle en Psychiatrie à vocation régionale Centre Hospitalier Henri Laborit Poitiers FranceUnité de Recherché Clinique Intersectorielle en Psychiatrie à vocation régionale Centre Hospitalier Henri Laborit Poitiers FranceUnité de Recherché Clinique Intersectorielle en Psychiatrie à vocation régionale Centre Hospitalier Henri Laborit Poitiers FranceUnité de Recherché Clinique Intersectorielle en Psychiatrie à vocation régionale Centre Hospitalier Henri Laborit Poitiers FranceAbstract Background Obsessive–compulsive disorder (OCD) is a complex disorder with 40%–60% of patients' refractory to treatment. Transcranial direct current stimulation (tDCS) has been shown to induce potent and long‐lasting effects on cortical excitability. The aim of the present clinical trial was to evaluate the therapeutic efficacy and tolerability of cathodal tDCS over the supplementary motor area (SMA) in treatment‐resistant OCD patients. Methods Twenty‐one treatment‐resistant OCD outpatients received 10 sessions of tDCS. Each treatment session consisted of 2 mA stimuli for 30 min. The cathode was positioned over the bilateral SMA and the anode over the right supraorbital area. Patients were evaluated at baseline, end of treatment, one‐month follow‐up, and three‐month follow‐up. Response to treatment was defined as at least a decrease of 35% on the Yale–Brown Obsessive–Compulsive Scale (YBOCS) and a score of 2 or less on the Clinical Global Impressions‐Improvement (CGI‐I) between baseline and 1‐month follow‐up. Results There was a significant decrease of YBOCS scores between baseline and one‐month assessment. At one month, five patients (24%) were considered as responders and 3 (15%) at 3 months. We also observed concomitant changes in depressive symptoms, and insight. The treatment was well tolerated. Short‐lasting side effects were reported as localized tingling sensation and skin redness. Conclusion Our results suggest that the use of cathodal tDCS over the SMA and anodal tDCS over the right supraorbital area in OCD treatment‐refractory patients is safe and promising to improve obsessive and compulsive symptoms. Large randomized controlled trials are needed to confirm this positive result.https://doi.org/10.1002/brb3.1648obsessive–compulsive disordersupplementary motor areatDCStreatment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ghina Harika‐Germaneau Damien Heit Armand Chatard Berangere Thirioux Nicolas Langbour Nemat Jaafari |
spellingShingle |
Ghina Harika‐Germaneau Damien Heit Armand Chatard Berangere Thirioux Nicolas Langbour Nemat Jaafari Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study Brain and Behavior obsessive–compulsive disorder supplementary motor area tDCS treatment |
author_facet |
Ghina Harika‐Germaneau Damien Heit Armand Chatard Berangere Thirioux Nicolas Langbour Nemat Jaafari |
author_sort |
Ghina Harika‐Germaneau |
title |
Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study |
title_short |
Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study |
title_full |
Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study |
title_fullStr |
Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study |
title_full_unstemmed |
Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study |
title_sort |
treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: an open label study |
publisher |
Wiley |
series |
Brain and Behavior |
issn |
2162-3279 |
publishDate |
2020-07-01 |
description |
Abstract Background Obsessive–compulsive disorder (OCD) is a complex disorder with 40%–60% of patients' refractory to treatment. Transcranial direct current stimulation (tDCS) has been shown to induce potent and long‐lasting effects on cortical excitability. The aim of the present clinical trial was to evaluate the therapeutic efficacy and tolerability of cathodal tDCS over the supplementary motor area (SMA) in treatment‐resistant OCD patients. Methods Twenty‐one treatment‐resistant OCD outpatients received 10 sessions of tDCS. Each treatment session consisted of 2 mA stimuli for 30 min. The cathode was positioned over the bilateral SMA and the anode over the right supraorbital area. Patients were evaluated at baseline, end of treatment, one‐month follow‐up, and three‐month follow‐up. Response to treatment was defined as at least a decrease of 35% on the Yale–Brown Obsessive–Compulsive Scale (YBOCS) and a score of 2 or less on the Clinical Global Impressions‐Improvement (CGI‐I) between baseline and 1‐month follow‐up. Results There was a significant decrease of YBOCS scores between baseline and one‐month assessment. At one month, five patients (24%) were considered as responders and 3 (15%) at 3 months. We also observed concomitant changes in depressive symptoms, and insight. The treatment was well tolerated. Short‐lasting side effects were reported as localized tingling sensation and skin redness. Conclusion Our results suggest that the use of cathodal tDCS over the SMA and anodal tDCS over the right supraorbital area in OCD treatment‐refractory patients is safe and promising to improve obsessive and compulsive symptoms. Large randomized controlled trials are needed to confirm this positive result. |
topic |
obsessive–compulsive disorder supplementary motor area tDCS treatment |
url |
https://doi.org/10.1002/brb3.1648 |
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