Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option

Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option

<p>Abstract</p> <p>Background</p> <p>Myxoid liposarcoma is a relatively common malignant soft tissue tumor, characterized by a (12;16) translocation resulting in a FUS-DDIT3 fusion gene playing a pivotal role in its tumorigenesis. Treatment options in patients with inop...

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Bibliographic Details
Main Authors: Szuhai Karoly, Bruijn Inge, Schrage Yvonne M, Willems Stefan M, Hogendoorn Pancras CW, Bovée Judith VMG
Format: Article
Language:English
Published: BMC 2010-09-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/257

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