GWAS-Top Polymorphisms Associated With Late-Onset Alzheimer Disease in Brazil: Pointing Out Possible New Culprits Among Non-Coding RNAs

GWAS-Top Polymorphisms Associated With Late-Onset Alzheimer Disease in Brazil: Pointing Out Possible New Culprits Among Non-Coding RNAs

Several genome-wide association studies (GWAS) have been carried out with late-onset Alzheimer’s disease (LOAD), mainly in European and Asian populations. Different polymorphisms were associated, but several of them without a functional explanation. GWAS are fundamental for identifying loci associat...

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Bibliographic Details
Main Authors: Gabriela Canalli Kretzschmar, Nina Moura Alencar, Saritha Suellen Lopes da Silva, Carla Daniela Sulzbach, Caroline Grisbach Meissner, Maria Luiza Petzl-Erler, Ricardo Lehtonen R. Souza, Angelica Beate Winter Boldt
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
Alzheimer’s disease
GWAS
APOE
BIN1
CELF1
lncRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.632314/full

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