Heterotrimeric G-protein signalers and RGSs in <i>Aspergillus fumigatus</i>
The heterotrimeric G-protein (G-protein) signaling pathway is one of the most important signaling pathways that transmit external signals into the inside of the cell, triggering appropriate biological responses. The external signals are sensed by various G-protein-coupled receptors (GPCRs) and trans...
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doaj-e2e5c85933b64668a12431135d6d7eea2020-11-25T04:06:42ZengMDPI AGPathogens2076-08172020-10-01990290210.3390/pathogens9110902Heterotrimeric G-protein signalers and RGSs in <i>Aspergillus fumigatus</i>Hee-Soo Park0Min-Ju Kim1Jae-Hyuk Yu2Kwang-Soo Shin3School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, KoreaSchool of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, KoreaDepartment of Bacteriology, University of Wisconsin, Madison, WI 53706, USADepartment of Microbiology, Graduate School, Daejeon University, Daejeon 34520, KoreaThe heterotrimeric G-protein (G-protein) signaling pathway is one of the most important signaling pathways that transmit external signals into the inside of the cell, triggering appropriate biological responses. The external signals are sensed by various G-protein-coupled receptors (GPCRs) and transmitted into G-proteins consisting of the α, β, and γ subunits. Regulators of G-protein signaling (RGSs) are the key controllers of G-protein signaling pathways. GPCRs, G-proteins, and RGSs are the primary upstream components of the G-protein signaling pathway, and they are highly conserved in most filamentous fungi, playing diverse roles in biological processes. Recent studies characterized the G-protein signaling components in the opportunistic pathogenic fungus <i>Aspergillus fumigatus</i>. In this review, we have summarized the characteristics and functions of GPCRs, G-proteins, and RGSs, and their regulatory roles in governing fungal growth, asexual development, germination, stress tolerance, and virulence in <i>A. fumigatus</i>.https://www.mdpi.com/2076-0817/9/11/902<i>Aspergillus fumigatus</i>regulators of G-protein signalingvirulenceG-proteinG-protein-coupled receptors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hee-Soo Park Min-Ju Kim Jae-Hyuk Yu Kwang-Soo Shin |
spellingShingle |
Hee-Soo Park Min-Ju Kim Jae-Hyuk Yu Kwang-Soo Shin Heterotrimeric G-protein signalers and RGSs in <i>Aspergillus fumigatus</i> Pathogens <i>Aspergillus fumigatus</i> regulators of G-protein signaling virulence G-protein G-protein-coupled receptors |
author_facet |
Hee-Soo Park Min-Ju Kim Jae-Hyuk Yu Kwang-Soo Shin |
author_sort |
Hee-Soo Park |
title |
Heterotrimeric G-protein signalers and RGSs in <i>Aspergillus fumigatus</i> |
title_short |
Heterotrimeric G-protein signalers and RGSs in <i>Aspergillus fumigatus</i> |
title_full |
Heterotrimeric G-protein signalers and RGSs in <i>Aspergillus fumigatus</i> |
title_fullStr |
Heterotrimeric G-protein signalers and RGSs in <i>Aspergillus fumigatus</i> |
title_full_unstemmed |
Heterotrimeric G-protein signalers and RGSs in <i>Aspergillus fumigatus</i> |
title_sort |
heterotrimeric g-protein signalers and rgss in <i>aspergillus fumigatus</i> |
publisher |
MDPI AG |
series |
Pathogens |
issn |
2076-0817 |
publishDate |
2020-10-01 |
description |
The heterotrimeric G-protein (G-protein) signaling pathway is one of the most important signaling pathways that transmit external signals into the inside of the cell, triggering appropriate biological responses. The external signals are sensed by various G-protein-coupled receptors (GPCRs) and transmitted into G-proteins consisting of the α, β, and γ subunits. Regulators of G-protein signaling (RGSs) are the key controllers of G-protein signaling pathways. GPCRs, G-proteins, and RGSs are the primary upstream components of the G-protein signaling pathway, and they are highly conserved in most filamentous fungi, playing diverse roles in biological processes. Recent studies characterized the G-protein signaling components in the opportunistic pathogenic fungus <i>Aspergillus fumigatus</i>. In this review, we have summarized the characteristics and functions of GPCRs, G-proteins, and RGSs, and their regulatory roles in governing fungal growth, asexual development, germination, stress tolerance, and virulence in <i>A. fumigatus</i>. |
topic |
<i>Aspergillus fumigatus</i> regulators of G-protein signaling virulence G-protein G-protein-coupled receptors |
url |
https://www.mdpi.com/2076-0817/9/11/902 |
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