Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties
The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide, especially as a result of our aging society, high caloric intake and sedentary lifestyle. Besides the well-known complications of T2DM on the cardiovascular system, the eyes, kidneys and nerves, bone strength is also impaired...
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Bioscientifica
2019-02-01
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doaj-e2ed7482fb354c29b236bf1ebea8c53b2020-11-25T00:31:06ZengBioscientificaEndocrine Connections2049-36142049-36142019-02-0183R55R70https://doi.org/10.1530/EC-18-0456Update on the impact of type 2 diabetes mellitus on bone metabolism and material propertiesAnn-Kristin Picke0Graeme Campbell1Nicola Napoli2Lorenz C Hofbauer3Martina Rauner4Institute of Comparative Molecular Endocrinology, Ulm University, Ulm, GermanyInstitute of Biomechanics, TUHH Hamburg University of Technology, Hamburg, GermanyDiabetes and Bone Network, Department Endocrinology and Diabetes, University Campus Bio-Medico of Rome, Rome, Italy; Division of Bone and Mineral Diseases, Washington University in St Louis, St Louis, Missouri, USADepartment of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Dresden, GermanyDepartment of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Dresden, GermanyThe prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide, especially as a result of our aging society, high caloric intake and sedentary lifestyle. Besides the well-known complications of T2DM on the cardiovascular system, the eyes, kidneys and nerves, bone strength is also impaired in diabetic patients. Patients with T2DM have a 40–70% increased risk for fractures, despite having a normal to increased bone mineral density, suggesting that other factors besides bone quantity must account for increased bone fragility. This review summarizes the current knowledge on the complex effects of T2DM on bone including effects on bone cells, bone material properties and other endocrine systems that subsequently affect bone, discusses the effects of T2DM medications on bone and concludes with a model identifying factors that may contribute to poor bone quality and increased bone fragility in T2DM.https://ec.bioscientifica.com/view/journals/ec/8/3/EC-18-0456.xmldiabetesbone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ann-Kristin Picke Graeme Campbell Nicola Napoli Lorenz C Hofbauer Martina Rauner |
spellingShingle |
Ann-Kristin Picke Graeme Campbell Nicola Napoli Lorenz C Hofbauer Martina Rauner Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties Endocrine Connections diabetes bone |
author_facet |
Ann-Kristin Picke Graeme Campbell Nicola Napoli Lorenz C Hofbauer Martina Rauner |
author_sort |
Ann-Kristin Picke |
title |
Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties |
title_short |
Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties |
title_full |
Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties |
title_fullStr |
Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties |
title_full_unstemmed |
Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties |
title_sort |
update on the impact of type 2 diabetes mellitus on bone metabolism and material properties |
publisher |
Bioscientifica |
series |
Endocrine Connections |
issn |
2049-3614 2049-3614 |
publishDate |
2019-02-01 |
description |
The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide, especially as a result of our aging society, high caloric intake and sedentary lifestyle. Besides the well-known complications of T2DM on the cardiovascular system, the eyes, kidneys and nerves, bone strength is also impaired in diabetic patients. Patients with T2DM have a 40–70% increased risk for fractures, despite having a normal to increased bone mineral density, suggesting that other factors besides bone quantity must account for increased bone fragility. This review summarizes the current knowledge on the complex effects of T2DM on bone including effects on bone cells, bone material properties and other endocrine systems that subsequently affect bone, discusses the effects of T2DM medications on bone and concludes with a model identifying factors that may contribute to poor bone quality and increased bone fragility in T2DM. |
topic |
diabetes bone |
url |
https://ec.bioscientifica.com/view/journals/ec/8/3/EC-18-0456.xml |
work_keys_str_mv |
AT annkristinpicke updateontheimpactoftype2diabetesmellitusonbonemetabolismandmaterialproperties AT graemecampbell updateontheimpactoftype2diabetesmellitusonbonemetabolismandmaterialproperties AT nicolanapoli updateontheimpactoftype2diabetesmellitusonbonemetabolismandmaterialproperties AT lorenzchofbauer updateontheimpactoftype2diabetesmellitusonbonemetabolismandmaterialproperties AT martinarauner updateontheimpactoftype2diabetesmellitusonbonemetabolismandmaterialproperties |
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