ER-to-Golgi Trafficking and Its Implication in Neurological Diseases
Membrane and secretory proteins are essential for almost every aspect of cellular function. These proteins are incorporated into ER-derived carriers and transported to the Golgi before being sorted for delivery to their final destination. Although ER-to-Golgi trafficking is highly conserved among eu...
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doaj-e2f15c64f6064cdca05607afb259de592020-11-25T02:03:23ZengMDPI AGCells2073-44092020-02-019240810.3390/cells9020408cells9020408ER-to-Golgi Trafficking and Its Implication in Neurological DiseasesBo Wang0Katherine R. Stanford1Mondira Kundu2Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USADepartment of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USADepartment of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USAMembrane and secretory proteins are essential for almost every aspect of cellular function. These proteins are incorporated into ER-derived carriers and transported to the Golgi before being sorted for delivery to their final destination. Although ER-to-Golgi trafficking is highly conserved among eukaryotes, several layers of complexity have been added to meet the increased demands of complex cell types in metazoans. The specialized morphology of neurons and the necessity for precise spatiotemporal control over membrane and secretory protein localization and function make them particularly vulnerable to defects in trafficking. This review summarizes the general mechanisms involved in ER-to-Golgi trafficking and highlights mutations in genes affecting this process, which are associated with neurological diseases in humans.https://www.mdpi.com/2073-4409/9/2/408copii traffickingendoplasmic reticulumgolgi apparatusneurological disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bo Wang Katherine R. Stanford Mondira Kundu |
spellingShingle |
Bo Wang Katherine R. Stanford Mondira Kundu ER-to-Golgi Trafficking and Its Implication in Neurological Diseases Cells copii trafficking endoplasmic reticulum golgi apparatus neurological disease |
author_facet |
Bo Wang Katherine R. Stanford Mondira Kundu |
author_sort |
Bo Wang |
title |
ER-to-Golgi Trafficking and Its Implication in Neurological Diseases |
title_short |
ER-to-Golgi Trafficking and Its Implication in Neurological Diseases |
title_full |
ER-to-Golgi Trafficking and Its Implication in Neurological Diseases |
title_fullStr |
ER-to-Golgi Trafficking and Its Implication in Neurological Diseases |
title_full_unstemmed |
ER-to-Golgi Trafficking and Its Implication in Neurological Diseases |
title_sort |
er-to-golgi trafficking and its implication in neurological diseases |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-02-01 |
description |
Membrane and secretory proteins are essential for almost every aspect of cellular function. These proteins are incorporated into ER-derived carriers and transported to the Golgi before being sorted for delivery to their final destination. Although ER-to-Golgi trafficking is highly conserved among eukaryotes, several layers of complexity have been added to meet the increased demands of complex cell types in metazoans. The specialized morphology of neurons and the necessity for precise spatiotemporal control over membrane and secretory protein localization and function make them particularly vulnerable to defects in trafficking. This review summarizes the general mechanisms involved in ER-to-Golgi trafficking and highlights mutations in genes affecting this process, which are associated with neurological diseases in humans. |
topic |
copii trafficking endoplasmic reticulum golgi apparatus neurological disease |
url |
https://www.mdpi.com/2073-4409/9/2/408 |
work_keys_str_mv |
AT bowang ertogolgitraffickinganditsimplicationinneurologicaldiseases AT katherinerstanford ertogolgitraffickinganditsimplicationinneurologicaldiseases AT mondirakundu ertogolgitraffickinganditsimplicationinneurologicaldiseases |
_version_ |
1724948658645893120 |