Density of Dermatophagoides spp. and Its Relationship with House-dust Mite Specific Serum IgE in Persistent Asthma
Background: Asthma is a chronic inflammation of the bronchial tree that emerges as a response to exogenous factors, such as allergens, irritants, and infections. Some asthmatic patients had been reported having symptoms of asthma due to house-dust mites (HDM) allergen exposure. It is associated with...
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doaj-e2f296824819496ba6212864ac4d98ad2021-03-01T01:04:26ZengCell and BioPharmaceutical InstituteMCBS (Molecular and Cellular Biomedical Sciences)2527-43842527-34422020-07-014261710.21705/mcbs.v4i2.9250Density of Dermatophagoides spp. and Its Relationship with House-dust Mite Specific Serum IgE in Persistent AsthmaAnnisa Mulia Anasis0Anna Rozaliyani1Heri Wibowo2Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, JakartaDepartment of Parasitology, Faculty of Medicine, Universitas Indonesia, JakartaDepartment of Parasitology, Faculty of Medicine, Universitas Indonesia, JakartaBackground: Asthma is a chronic inflammation of the bronchial tree that emerges as a response to exogenous factors, such as allergens, irritants, and infections. Some asthmatic patients had been reported having symptoms of asthma due to house-dust mites (HDM) allergen exposure. It is associated with immune responses which were increased in the form of specific Immunoglobulin E (IgE) production against HDM allergens. This case-control study aimed to determine the HDM profiles in persistent asthmatic patients, including density of mites, as well as its relationship with specific IgE anti-HDM serum levels. Materials and Methods: A total of 13 patients with persistent asthma and 12 control patients had their specific anti-HDM IgE levels examined using Immulite 2000 xpi. The house dust samples were taken and analyzed with the Fain method. Results: The results have shown that 69% of patients in the persistent asthma group and 25% of normal patients were positive for IgE anti-HDM. Dermatophagoides pteronyssinus is a predominant species with a total of 120 mites (83.9%) of 143 mites. Correlation analysis indicated a positive relationship between IgE anti-HDM levels within the serums of patients and the density of mites in the dust obtained from bedroom spaces (Spearmen Rho, R=0.35, p=0.04). Conclusion: Positive IgE anti-HDM patients in the persistent asthma group were higher (69%) than those in the clinically normal group (25%). The density of mites were dominated by D. Pteronyssinus. The bedroom-dust mites density revealed a positive correlation with serum IgE anti-HDM levels in persistent asthma patients. Keywords: asthma, density, Dermatophagoides spp.,IgEhttps://cellbiopharm.com/ojs/index.php/MCBS/article/view/92 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Annisa Mulia Anasis Anna Rozaliyani Heri Wibowo |
spellingShingle |
Annisa Mulia Anasis Anna Rozaliyani Heri Wibowo Density of Dermatophagoides spp. and Its Relationship with House-dust Mite Specific Serum IgE in Persistent Asthma MCBS (Molecular and Cellular Biomedical Sciences) |
author_facet |
Annisa Mulia Anasis Anna Rozaliyani Heri Wibowo |
author_sort |
Annisa Mulia Anasis |
title |
Density of Dermatophagoides spp. and Its Relationship with House-dust Mite Specific Serum IgE in Persistent Asthma |
title_short |
Density of Dermatophagoides spp. and Its Relationship with House-dust Mite Specific Serum IgE in Persistent Asthma |
title_full |
Density of Dermatophagoides spp. and Its Relationship with House-dust Mite Specific Serum IgE in Persistent Asthma |
title_fullStr |
Density of Dermatophagoides spp. and Its Relationship with House-dust Mite Specific Serum IgE in Persistent Asthma |
title_full_unstemmed |
Density of Dermatophagoides spp. and Its Relationship with House-dust Mite Specific Serum IgE in Persistent Asthma |
title_sort |
density of dermatophagoides spp. and its relationship with house-dust mite specific serum ige in persistent asthma |
publisher |
Cell and BioPharmaceutical Institute |
series |
MCBS (Molecular and Cellular Biomedical Sciences) |
issn |
2527-4384 2527-3442 |
publishDate |
2020-07-01 |
description |
Background: Asthma is a chronic inflammation of the bronchial tree that emerges as a response to exogenous factors, such as allergens, irritants, and infections. Some asthmatic patients had been reported having symptoms of asthma due to house-dust mites (HDM) allergen exposure. It is associated with immune responses which were increased in the form of specific Immunoglobulin E (IgE) production against HDM allergens. This case-control study aimed to determine the HDM profiles in persistent asthmatic patients, including density of mites, as well as its relationship with specific IgE anti-HDM serum levels.
Materials and Methods: A total of 13 patients with persistent asthma and 12 control patients had their specific anti-HDM IgE levels examined using Immulite 2000 xpi. The house dust samples were taken and analyzed with the Fain method.
Results: The results have shown that 69% of patients in the persistent asthma group and 25% of normal patients were positive for IgE anti-HDM. Dermatophagoides pteronyssinus is a predominant species with a total of 120 mites (83.9%) of 143 mites. Correlation analysis indicated a positive relationship between IgE anti-HDM levels within the serums of patients and the density of mites in the dust obtained from bedroom spaces (Spearmen Rho, R=0.35, p=0.04).
Conclusion: Positive IgE anti-HDM patients in the persistent asthma group were higher (69%) than those in the clinically normal group (25%). The density of mites were dominated by D. Pteronyssinus. The bedroom-dust mites density revealed a positive correlation with serum IgE anti-HDM levels in persistent asthma patients.
Keywords: asthma, density, Dermatophagoides spp.,IgE |
url |
https://cellbiopharm.com/ojs/index.php/MCBS/article/view/92 |
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