Advancements in Hydrogel-Based Drug Sustained Release Systems for Bone Tissue Engineering
Bone defects caused by injury, disease, or congenital deformity remain a major health concern, and efficiently regenerating bone is a prominent clinical demand worldwide. However, bone regeneration is an intricate process that requires concerted participation of both cells and bioactive factors. Mim...
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2020-05-01
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doaj-e2f480a2946b4f5c9b3ca859cbbc41b82020-11-25T03:00:28ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-05-011110.3389/fphar.2020.00622542297Advancements in Hydrogel-Based Drug Sustained Release Systems for Bone Tissue EngineeringYunfan Zhang0Tingting Yu1Liying Peng2Qiannan Sun3Yan Wei4Bing Han5Department of Orthodontics, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, ChinaDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, ChinaDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, ChinaDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, ChinaDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, ChinaDepartment of Orthodontics, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, ChinaBone defects caused by injury, disease, or congenital deformity remain a major health concern, and efficiently regenerating bone is a prominent clinical demand worldwide. However, bone regeneration is an intricate process that requires concerted participation of both cells and bioactive factors. Mimicking physiological bone healing procedures, the sustained release of bioactive molecules plays a vital role in creating an optimal osteogenic microenvironment and achieving promising bone repair outcomes. The utilization of biomaterial scaffolds can positively affect the osteogenesis process by integrating cells with bioactive factors in a proper way. A high water content, tunable physio-mechanical properties, and diverse synthetic strategies make hydrogels ideal cell carriers and controlled drug release reservoirs. Herein, we reviewed the current advancements in hydrogel-based drug sustained release systems that have delivered osteogenesis-inducing peptides, nucleic acids, and other bioactive molecules in bone tissue engineering (BTE).https://www.frontiersin.org/article/10.3389/fphar.2020.00622/fullhydrogelsustained drug releasebone tissue engineeringgrowth factorsmesenchymal stem cells |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yunfan Zhang Tingting Yu Liying Peng Qiannan Sun Yan Wei Bing Han |
spellingShingle |
Yunfan Zhang Tingting Yu Liying Peng Qiannan Sun Yan Wei Bing Han Advancements in Hydrogel-Based Drug Sustained Release Systems for Bone Tissue Engineering Frontiers in Pharmacology hydrogel sustained drug release bone tissue engineering growth factors mesenchymal stem cells |
author_facet |
Yunfan Zhang Tingting Yu Liying Peng Qiannan Sun Yan Wei Bing Han |
author_sort |
Yunfan Zhang |
title |
Advancements in Hydrogel-Based Drug Sustained Release Systems for Bone Tissue Engineering |
title_short |
Advancements in Hydrogel-Based Drug Sustained Release Systems for Bone Tissue Engineering |
title_full |
Advancements in Hydrogel-Based Drug Sustained Release Systems for Bone Tissue Engineering |
title_fullStr |
Advancements in Hydrogel-Based Drug Sustained Release Systems for Bone Tissue Engineering |
title_full_unstemmed |
Advancements in Hydrogel-Based Drug Sustained Release Systems for Bone Tissue Engineering |
title_sort |
advancements in hydrogel-based drug sustained release systems for bone tissue engineering |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2020-05-01 |
description |
Bone defects caused by injury, disease, or congenital deformity remain a major health concern, and efficiently regenerating bone is a prominent clinical demand worldwide. However, bone regeneration is an intricate process that requires concerted participation of both cells and bioactive factors. Mimicking physiological bone healing procedures, the sustained release of bioactive molecules plays a vital role in creating an optimal osteogenic microenvironment and achieving promising bone repair outcomes. The utilization of biomaterial scaffolds can positively affect the osteogenesis process by integrating cells with bioactive factors in a proper way. A high water content, tunable physio-mechanical properties, and diverse synthetic strategies make hydrogels ideal cell carriers and controlled drug release reservoirs. Herein, we reviewed the current advancements in hydrogel-based drug sustained release systems that have delivered osteogenesis-inducing peptides, nucleic acids, and other bioactive molecules in bone tissue engineering (BTE). |
topic |
hydrogel sustained drug release bone tissue engineering growth factors mesenchymal stem cells |
url |
https://www.frontiersin.org/article/10.3389/fphar.2020.00622/full |
work_keys_str_mv |
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