Animal Model for Lower Urinary Tract Dysfunction in Parkinson’s Disease
Although Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and subsequent motor symptoms, various non-motor symptoms often precede these other symptoms. While motor symptoms are certainly burdensome, a wide range of non-motor symptoms have emerged...
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doaj-e30463b65e554047b5ce56b2ccd9e1902020-11-25T03:43:32ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-01216520652010.3390/ijms21186520Animal Model for Lower Urinary Tract Dysfunction in Parkinson’s DiseaseTakeya Kitta0Mifuka Ouchi1Hiroki Chiba2Madoka Higuchi3Mio Togo4Yui Abe-Takahashi5Naohisa Kusakabe6Nobuo Shinohara7Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8648, JapanSchool of Rehabilitation Sciences, Health Sciences University of Hokkaido, Tobetsu 061-0293, JapanDepartment of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8648, JapanDepartment of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8648, JapanDepartment of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8648, JapanDepartment of Physical Therapy, Faculty of Health Sciences Hokkaido University of Science, Sapporo 006-8585, JapanDepartment of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8648, JapanDepartment of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8648, JapanAlthough Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and subsequent motor symptoms, various non-motor symptoms often precede these other symptoms. While motor symptoms are certainly burdensome, a wide range of non-motor symptoms have emerged as the key determinant of the quality of life in PD patients. The prevalence of lower urinary tract symptoms differs according to the study, with ranges between 27% and 63.9%. These can be influenced by the stage of disease, the presence of lower urinary tract-related comorbidities, and parallels with other manifestations of autonomic dysfunction. Animal models can provide a platform for investigating the mechanisms of PD-related dysfunction and for the assessment of novel treatment strategies. Animal research efforts have been primarily focused on PD motor signs and symptoms. However, the etiology of lower urinary tract dysfunction in PD has yet to be definitively clarified. Several animal PD models are available, each of which has a different effect on the autonomic nervous system. In this article, we review the various lower urinary tract dysfunction animal PD models. We additionally discuss techniques for determining the appropriate model for evaluating the development of lower urinary tract dysfunction treatments.https://www.mdpi.com/1422-0067/21/18/6520Parkinson’s diseaseanimal modellower urinary tract dysfunctionnon-motor symptomoveractive bladderdetrusor overactivity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takeya Kitta Mifuka Ouchi Hiroki Chiba Madoka Higuchi Mio Togo Yui Abe-Takahashi Naohisa Kusakabe Nobuo Shinohara |
spellingShingle |
Takeya Kitta Mifuka Ouchi Hiroki Chiba Madoka Higuchi Mio Togo Yui Abe-Takahashi Naohisa Kusakabe Nobuo Shinohara Animal Model for Lower Urinary Tract Dysfunction in Parkinson’s Disease International Journal of Molecular Sciences Parkinson’s disease animal model lower urinary tract dysfunction non-motor symptom overactive bladder detrusor overactivity |
author_facet |
Takeya Kitta Mifuka Ouchi Hiroki Chiba Madoka Higuchi Mio Togo Yui Abe-Takahashi Naohisa Kusakabe Nobuo Shinohara |
author_sort |
Takeya Kitta |
title |
Animal Model for Lower Urinary Tract Dysfunction in Parkinson’s Disease |
title_short |
Animal Model for Lower Urinary Tract Dysfunction in Parkinson’s Disease |
title_full |
Animal Model for Lower Urinary Tract Dysfunction in Parkinson’s Disease |
title_fullStr |
Animal Model for Lower Urinary Tract Dysfunction in Parkinson’s Disease |
title_full_unstemmed |
Animal Model for Lower Urinary Tract Dysfunction in Parkinson’s Disease |
title_sort |
animal model for lower urinary tract dysfunction in parkinson’s disease |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-09-01 |
description |
Although Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and subsequent motor symptoms, various non-motor symptoms often precede these other symptoms. While motor symptoms are certainly burdensome, a wide range of non-motor symptoms have emerged as the key determinant of the quality of life in PD patients. The prevalence of lower urinary tract symptoms differs according to the study, with ranges between 27% and 63.9%. These can be influenced by the stage of disease, the presence of lower urinary tract-related comorbidities, and parallels with other manifestations of autonomic dysfunction. Animal models can provide a platform for investigating the mechanisms of PD-related dysfunction and for the assessment of novel treatment strategies. Animal research efforts have been primarily focused on PD motor signs and symptoms. However, the etiology of lower urinary tract dysfunction in PD has yet to be definitively clarified. Several animal PD models are available, each of which has a different effect on the autonomic nervous system. In this article, we review the various lower urinary tract dysfunction animal PD models. We additionally discuss techniques for determining the appropriate model for evaluating the development of lower urinary tract dysfunction treatments. |
topic |
Parkinson’s disease animal model lower urinary tract dysfunction non-motor symptom overactive bladder detrusor overactivity |
url |
https://www.mdpi.com/1422-0067/21/18/6520 |
work_keys_str_mv |
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