Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity
A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus...
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2010-12-01
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Online Access: | http://www.mdpi.com/1420-3049/16/1/175/ |
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doaj-e314a41578344275a4c22922d05fe5472020-11-25T02:09:39ZengMDPI AGMolecules1420-30492010-12-0116117518910.3390/molecules16010175Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial ActivityFidel Martínez-GutiérrezFrancisco MéndezRoberto MartínezMarco Martín González-ChávezCuaúhtemoc Pérez-GonzálezA series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis. Quantitative studies of their structure-activity relationship using a simple linear regression analysis were applied to explore the correlation between the biological activity and the charges on acidic hydrogen atoms in the synthesized compounds. http://www.mdpi.com/1420-3049/16/1/175/benzimidazolesulphonamideMRSAantibacterial activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fidel Martínez-Gutiérrez Francisco Méndez Roberto Martínez Marco Martín González-Chávez Cuaúhtemoc Pérez-González |
spellingShingle |
Fidel Martínez-Gutiérrez Francisco Méndez Roberto Martínez Marco Martín González-Chávez Cuaúhtemoc Pérez-González Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity Molecules benzimidazole sulphonamide MRSA antibacterial activity |
author_facet |
Fidel Martínez-Gutiérrez Francisco Méndez Roberto Martínez Marco Martín González-Chávez Cuaúhtemoc Pérez-González |
author_sort |
Fidel Martínez-Gutiérrez |
title |
Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity |
title_short |
Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity |
title_full |
Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity |
title_fullStr |
Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity |
title_full_unstemmed |
Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity |
title_sort |
design and synthesis of anti-mrsa benzimidazolylbenzene-sulfonamides. qsar studies for prediction of antibacterial activity |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2010-12-01 |
description |
A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis. Quantitative studies of their structure-activity relationship using a simple linear regression analysis were applied to explore the correlation between the biological activity and the charges on acidic hydrogen atoms in the synthesized compounds. |
topic |
benzimidazole sulphonamide MRSA antibacterial activity |
url |
http://www.mdpi.com/1420-3049/16/1/175/ |
work_keys_str_mv |
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