Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity

Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity

A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus...

Full description

Bibliographic Details
Main Authors: Fidel Martínez-Gutiérrez, Francisco Méndez, Roberto Martínez, Marco Martín González-Chávez, Cuaúhtemoc Pérez-González
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Molecules
Subjects:
benzimidazole
sulphonamide
MRSA
antibacterial activity
Online Access:http://www.mdpi.com/1420-3049/16/1/175/
id doaj-e314a41578344275a4c22922d05fe547
record_format Article
spelling doaj-e314a41578344275a4c22922d05fe5472020-11-25T02:09:39ZengMDPI AGMolecules1420-30492010-12-0116117518910.3390/molecules16010175Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial ActivityFidel Martínez-GutiérrezFrancisco MéndezRoberto MartínezMarco Martín González-ChávezCuaúhtemoc Pérez-GonzálezA series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis. Quantitative studies of their structure-activity relationship using a simple linear regression analysis were applied to explore the correlation between the biological activity and the charges on acidic hydrogen atoms in the synthesized compounds. http://www.mdpi.com/1420-3049/16/1/175/benzimidazolesulphonamideMRSAantibacterial activity
collection DOAJ
language English
format Article
sources DOAJ
author Fidel Martínez-Gutiérrez
Francisco Méndez
Roberto Martínez
Marco Martín González-Chávez
Cuaúhtemoc Pérez-González
spellingShingle Fidel Martínez-Gutiérrez
Francisco Méndez
Roberto Martínez
Marco Martín González-Chávez
Cuaúhtemoc Pérez-González
Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity
Molecules
benzimidazole
sulphonamide
MRSA
antibacterial activity
author_facet Fidel Martínez-Gutiérrez
Francisco Méndez
Roberto Martínez
Marco Martín González-Chávez
Cuaúhtemoc Pérez-González
author_sort Fidel Martínez-Gutiérrez
title Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity
title_short Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity
title_full Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity
title_fullStr Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity
title_full_unstemmed Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity
title_sort design and synthesis of anti-mrsa benzimidazolylbenzene-sulfonamides. qsar studies for prediction of antibacterial activity
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2010-12-01
description A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis. Quantitative studies of their structure-activity relationship using a simple linear regression analysis were applied to explore the correlation between the biological activity and the charges on acidic hydrogen atoms in the synthesized compounds.
topic benzimidazole
sulphonamide
MRSA
antibacterial activity
url http://www.mdpi.com/1420-3049/16/1/175/
work_keys_str_mv AT fidelmartinezgutierrez designandsynthesisofantimrsabenzimidazolylbenzenesulfonamidesqsarstudiesforpredictionofantibacterialactivity
AT franciscomendez designandsynthesisofantimrsabenzimidazolylbenzenesulfonamidesqsarstudiesforpredictionofantibacterialactivity
AT robertomartinez designandsynthesisofantimrsabenzimidazolylbenzenesulfonamidesqsarstudiesforpredictionofantibacterialactivity
AT marcomartingonzalezchavez designandsynthesisofantimrsabenzimidazolylbenzenesulfonamidesqsarstudiesforpredictionofantibacterialactivity
AT cuauhtemocperezgonzalez designandsynthesisofantimrsabenzimidazolylbenzenesulfonamidesqsarstudiesforpredictionofantibacterialactivity
_version_ 1724922420141228032

Similar Items