Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury

Aquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide, and hydrogen peroxide mediated oxidative stress has been implicated in liver injury. Here, the authors report the development of an anti-AQP3 monoclonal antibody, which alleviates liver injury in multiple mouse models.

Bibliographic Details
Main Authors:	Mariko Hara-Chikuma, Manami Tanaka, Alan S. Verkman, Masato Yasui
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-19491-5

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spelling	doaj-e318202226c44321ab0d1805baa94b422021-05-11T09:13:16ZengNature Publishing GroupNature Communications2041-17232020-11-0111111410.1038/s41467-020-19491-5Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injuryMariko Hara-Chikuma0Manami Tanaka1Alan S. Verkman2Masato Yasui3Department of Pharmacology, School of Medicine, Keio UniversityDepartment of Pharmacology, School of Medicine, Keio UniversityDepartments of Medicine and Physiology, University of California San FranciscoDepartment of Pharmacology, School of Medicine, Keio UniversityAquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide, and hydrogen peroxide mediated oxidative stress has been implicated in liver injury. Here, the authors report the development of an anti-AQP3 monoclonal antibody, which alleviates liver injury in multiple mouse models.https://doi.org/10.1038/s41467-020-19491-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mariko Hara-Chikuma Manami Tanaka Alan S. Verkman Masato Yasui
spellingShingle	Mariko Hara-Chikuma Manami Tanaka Alan S. Verkman Masato Yasui Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury Nature Communications
author_facet	Mariko Hara-Chikuma Manami Tanaka Alan S. Verkman Masato Yasui
author_sort	Mariko Hara-Chikuma
title	Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
title_short	Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
title_full	Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
title_fullStr	Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
title_full_unstemmed	Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
title_sort	inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-11-01
description	Aquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide, and hydrogen peroxide mediated oxidative stress has been implicated in liver injury. Here, the authors report the development of an anti-AQP3 monoclonal antibody, which alleviates liver injury in multiple mouse models.
url	https://doi.org/10.1038/s41467-020-19491-5
work_keys_str_mv	AT marikoharachikuma inhibitionofaquaporin3inmacrophagesbyamonoclonalantibodyaspotentialtherapyforliverinjury AT manamitanaka inhibitionofaquaporin3inmacrophagesbyamonoclonalantibodyaspotentialtherapyforliverinjury AT alansverkman inhibitionofaquaporin3inmacrophagesbyamonoclonalantibodyaspotentialtherapyforliverinjury AT masatoyasui inhibitionofaquaporin3inmacrophagesbyamonoclonalantibodyaspotentialtherapyforliverinjury
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Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury

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