Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors
Moonlighting proteins can perform one or more additional functions besides their primary role. It has been posited that a protein can acquire a moonlighting function through a gradual evolutionary process, which is favored when the primary and secondary functions are exerted in different cellular co...
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doaj-e318a31a6dcc4c2e9c596f32f7988a422020-11-25T03:18:22ZengMDPI AGCells2073-44092020-06-0191554155410.3390/cells9061554Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing FactorsMaria Patrizia Somma0Evgeniya N. Andreyeva1Gera A. Pavlova2Claudia Pellacani3Elisabetta Bucciarelli4Julia V. Popova5Silvia Bonaccorsi6Alexey V. Pindyurin7Maurizio Gatti8IBPM CNR c/o Department of Biology and Biotechnology, Sapienza University of Rome, 00185 Rome, ItalyInstitute of Molecular and Cellular Biology, Siberian Branch of RAS, 630090 Novosibirsk, RussiaInstitute of Molecular and Cellular Biology, Siberian Branch of RAS, 630090 Novosibirsk, RussiaIBPM CNR c/o Department of Biology and Biotechnology, Sapienza University of Rome, 00185 Rome, ItalyIBPM CNR c/o Department of Biology and Biotechnology, Sapienza University of Rome, 00185 Rome, ItalyInstitute of Molecular and Cellular Biology, Siberian Branch of RAS, 630090 Novosibirsk, RussiaDepartment of Biology and Biotechnology, Sapienza University of Rome, 00185 Rome, ItalyInstitute of Molecular and Cellular Biology, Siberian Branch of RAS, 630090 Novosibirsk, RussiaIBPM CNR c/o Department of Biology and Biotechnology, Sapienza University of Rome, 00185 Rome, ItalyMoonlighting proteins can perform one or more additional functions besides their primary role. It has been posited that a protein can acquire a moonlighting function through a gradual evolutionary process, which is favored when the primary and secondary functions are exerted in different cellular compartments. Transcription factors (TFs) and splicing factors (SFs) control processes that occur in interphase nuclei and are strongly reduced during cell division, and are therefore in a favorable situation to evolve moonlighting mitotic functions. However, recently published moonlighting protein databases, which comprise almost 400 proteins, do not include TFs and SFs with secondary mitotic functions. We searched the literature and found several TFs and SFs with bona fide moonlighting mitotic functions, namely they localize to specific mitotic structure(s), interact with proteins enriched in the same structure(s), and are required for proper morphology and functioning of the structure(s). In addition, we describe TFs and SFs that localize to mitotic structures but cannot be classified as moonlighting proteins due to insufficient data on their biochemical interactions and mitotic roles. Nevertheless, we hypothesize that most TFs and SFs with specific mitotic localizations have either minor or redundant moonlighting functions, or are evolving towards the acquisition of these functions.https://www.mdpi.com/2073-4409/9/6/1554transcription factorssplicing factorsmultifunctional proteinsprotein moonlightingmitosismicrotubules |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Patrizia Somma Evgeniya N. Andreyeva Gera A. Pavlova Claudia Pellacani Elisabetta Bucciarelli Julia V. Popova Silvia Bonaccorsi Alexey V. Pindyurin Maurizio Gatti |
spellingShingle |
Maria Patrizia Somma Evgeniya N. Andreyeva Gera A. Pavlova Claudia Pellacani Elisabetta Bucciarelli Julia V. Popova Silvia Bonaccorsi Alexey V. Pindyurin Maurizio Gatti Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors Cells transcription factors splicing factors multifunctional proteins protein moonlighting mitosis microtubules |
author_facet |
Maria Patrizia Somma Evgeniya N. Andreyeva Gera A. Pavlova Claudia Pellacani Elisabetta Bucciarelli Julia V. Popova Silvia Bonaccorsi Alexey V. Pindyurin Maurizio Gatti |
author_sort |
Maria Patrizia Somma |
title |
Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors |
title_short |
Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors |
title_full |
Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors |
title_fullStr |
Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors |
title_full_unstemmed |
Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors |
title_sort |
moonlighting in mitosis: analysis of the mitotic functions of transcription and splicing factors |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-06-01 |
description |
Moonlighting proteins can perform one or more additional functions besides their primary role. It has been posited that a protein can acquire a moonlighting function through a gradual evolutionary process, which is favored when the primary and secondary functions are exerted in different cellular compartments. Transcription factors (TFs) and splicing factors (SFs) control processes that occur in interphase nuclei and are strongly reduced during cell division, and are therefore in a favorable situation to evolve moonlighting mitotic functions. However, recently published moonlighting protein databases, which comprise almost 400 proteins, do not include TFs and SFs with secondary mitotic functions. We searched the literature and found several TFs and SFs with bona fide moonlighting mitotic functions, namely they localize to specific mitotic structure(s), interact with proteins enriched in the same structure(s), and are required for proper morphology and functioning of the structure(s). In addition, we describe TFs and SFs that localize to mitotic structures but cannot be classified as moonlighting proteins due to insufficient data on their biochemical interactions and mitotic roles. Nevertheless, we hypothesize that most TFs and SFs with specific mitotic localizations have either minor or redundant moonlighting functions, or are evolving towards the acquisition of these functions. |
topic |
transcription factors splicing factors multifunctional proteins protein moonlighting mitosis microtubules |
url |
https://www.mdpi.com/2073-4409/9/6/1554 |
work_keys_str_mv |
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