Variability in Cardiac miRNA-122 Level Determines Therapeutic Potential of miRNA-Regulated AAV Vectors

Variability in Cardiac miRNA-122 Level Determines Therapeutic Potential of miRNA-Regulated AAV Vectors

Systemically delivered adeno-associated viral vector serotype 9 (AAV9) effectively transduces murine heart, but provides transgene expression also in liver and skeletal muscles. Improvement of the selectivity of transgene expression can be achieved through incorporation of target sites (TSs) for miR...

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Bibliographic Details
Main Authors:	Izabela Kraszewska, Mateusz Tomczyk, Kalina Andrysiak, Monika Biniecka, Anja Geisler, Henry Fechner, Michał Zembala, Jacek Stępniewski, Józef Dulak, Agnieszka Jaźwa-Kusior
Format:	Article
Language:	English
Published:	Elsevier 2020-06-01
Series:	Molecular Therapy: Methods & Clinical Development
Online Access:	http://www.sciencedirect.com/science/article/pii/S2329050120300930

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