Discovery of Biomarkers for Osteosarcoma by Proteomics Approaches
Osteosarcomas are the most common malignant bone tumors, and the identification of useful tumor biomarkers and target proteins is required to predict the clinical outcome of patients and therapeutic response as well as to develop novel therapeutic strategies. Global protein expression studies, namel...
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doaj-e31a5860264b45c9a006e9c8055514eb2020-11-24T22:23:45ZengHindawi LimitedSarcoma1357-714X1369-16432012-01-01201210.1155/2012/425636425636Discovery of Biomarkers for Osteosarcoma by Proteomics ApproachesYoshiyuki Suehara0Daisuke Kubota1Kazutaka Kikuta2Kazuo Kaneko3Akira Kawai4Tadashi Kondo5Department of Orthopedic Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Orthopedic Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDepartment of Orthopedic Surgery, Tachikawa Memorial Hospital, 4-2-22 Nishikichou, Tachikawa, Tokyo 190-8531, JapanDepartment of Orthopedic Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanDivision of Musculoskeletal Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JapanDivision of Pharmacoproteomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, JapanOsteosarcomas are the most common malignant bone tumors, and the identification of useful tumor biomarkers and target proteins is required to predict the clinical outcome of patients and therapeutic response as well as to develop novel therapeutic strategies. Global protein expression studies, namely, proteomic studies, can offer important clues to understanding the tumor biology that cannot be obtained by other approaches. These studies, such as two-dimensional gel electrophoresis and mass spectrometry, have provided protein expression profiles of osteosarcoma that can be used to develop novel diagnostic and therapeutic biomarkers, as well as to understand biology of tumor progression and malignancy. In this paper, a brief description of the methodology will be provided followed by a few examples of the recent proteomic studies that have generated new information regarding osteosarcomas.http://dx.doi.org/10.1155/2012/425636 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yoshiyuki Suehara Daisuke Kubota Kazutaka Kikuta Kazuo Kaneko Akira Kawai Tadashi Kondo |
spellingShingle |
Yoshiyuki Suehara Daisuke Kubota Kazutaka Kikuta Kazuo Kaneko Akira Kawai Tadashi Kondo Discovery of Biomarkers for Osteosarcoma by Proteomics Approaches Sarcoma |
author_facet |
Yoshiyuki Suehara Daisuke Kubota Kazutaka Kikuta Kazuo Kaneko Akira Kawai Tadashi Kondo |
author_sort |
Yoshiyuki Suehara |
title |
Discovery of Biomarkers for Osteosarcoma by Proteomics Approaches |
title_short |
Discovery of Biomarkers for Osteosarcoma by Proteomics Approaches |
title_full |
Discovery of Biomarkers for Osteosarcoma by Proteomics Approaches |
title_fullStr |
Discovery of Biomarkers for Osteosarcoma by Proteomics Approaches |
title_full_unstemmed |
Discovery of Biomarkers for Osteosarcoma by Proteomics Approaches |
title_sort |
discovery of biomarkers for osteosarcoma by proteomics approaches |
publisher |
Hindawi Limited |
series |
Sarcoma |
issn |
1357-714X 1369-1643 |
publishDate |
2012-01-01 |
description |
Osteosarcomas are the most common malignant bone tumors, and the identification of useful tumor biomarkers and target proteins is required to predict the clinical outcome of patients and therapeutic response as well as to develop novel therapeutic strategies. Global protein expression studies, namely, proteomic studies, can offer important clues to understanding the tumor biology that cannot be obtained by other approaches. These studies, such as two-dimensional gel electrophoresis and mass spectrometry, have provided protein expression profiles of osteosarcoma that can be used to develop novel diagnostic and therapeutic biomarkers, as well as to understand biology of tumor progression and malignancy. In this paper, a brief description of the methodology will be provided followed by a few examples of the recent proteomic studies that have generated new information regarding osteosarcomas. |
url |
http://dx.doi.org/10.1155/2012/425636 |
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