IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection
A large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent mechanisms useful in defense against pathogenic microorganisms and to reduce immune activation. IgA is active against several pathogens, including rotavirus, poliovirus, influenza virus, and SARS-CoV-2. It prot...
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doaj-e32d349af1724b2681644156e4715e0a2021-04-06T09:14:55ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-04-011110.3389/fcimb.2021.655896655896IgA Antibodies and IgA Deficiency in SARS-CoV-2 InfectionIsabella Quinti0Eva Piano Mortari1Ane Fernandez Salinas2Cinzia Milito3Rita Carsetti4Department of Molecular Medicine, Sapienza University of Rome, Rome, ItalyDepartment of Laboratory Medicine, Research Area Multimodal Medicine, Diagnostic Immunology and Research Unit, Bambino Gesù Children’s Hospital IRCCS, Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, Rome, ItalyDepartment of Laboratory Medicine, Research Area Multimodal Medicine, Diagnostic Immunology and Research Unit, Bambino Gesù Children’s Hospital IRCCS, Rome, ItalyA large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent mechanisms useful in defense against pathogenic microorganisms and to reduce immune activation. IgA is active against several pathogens, including rotavirus, poliovirus, influenza virus, and SARS-CoV-2. It protects the epithelial barriers from pathogens and modulates excessive immune responses in inflammatory diseases. An early SARS-CoV-2 specific humoral response is dominated by IgA antibodies responses greatly contributing to virus neutralization. The lack of anti-SARS-Cov-2 IgA and secretory IgA (sIgA) might represent a possible cause of COVID-19 severity, vaccine failure, and possible cause of prolonged viral shedding in patients with Primary Antibody Deficiencies, including patients with Selective IgA Deficiency. Differently from other primary antibody deficiency entities, Selective IgA Deficiency occurs in the vast majority of patients as an asymptomatic condition, and it is often an unrecognized, Studies are needed to clarify the open questions raised by possible consequences of a lack of an IgA response to SARS-CoV-2.https://www.frontiersin.org/articles/10.3389/fcimb.2021.655896/fullIgAsecretory IgASARS-Cov-2selective IgA deficiencyinfectivity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Isabella Quinti Eva Piano Mortari Ane Fernandez Salinas Cinzia Milito Rita Carsetti |
spellingShingle |
Isabella Quinti Eva Piano Mortari Ane Fernandez Salinas Cinzia Milito Rita Carsetti IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection Frontiers in Cellular and Infection Microbiology IgA secretory IgA SARS-Cov-2 selective IgA deficiency infectivity |
author_facet |
Isabella Quinti Eva Piano Mortari Ane Fernandez Salinas Cinzia Milito Rita Carsetti |
author_sort |
Isabella Quinti |
title |
IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection |
title_short |
IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection |
title_full |
IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection |
title_fullStr |
IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection |
title_full_unstemmed |
IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection |
title_sort |
iga antibodies and iga deficiency in sars-cov-2 infection |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2021-04-01 |
description |
A large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent mechanisms useful in defense against pathogenic microorganisms and to reduce immune activation. IgA is active against several pathogens, including rotavirus, poliovirus, influenza virus, and SARS-CoV-2. It protects the epithelial barriers from pathogens and modulates excessive immune responses in inflammatory diseases. An early SARS-CoV-2 specific humoral response is dominated by IgA antibodies responses greatly contributing to virus neutralization. The lack of anti-SARS-Cov-2 IgA and secretory IgA (sIgA) might represent a possible cause of COVID-19 severity, vaccine failure, and possible cause of prolonged viral shedding in patients with Primary Antibody Deficiencies, including patients with Selective IgA Deficiency. Differently from other primary antibody deficiency entities, Selective IgA Deficiency occurs in the vast majority of patients as an asymptomatic condition, and it is often an unrecognized, Studies are needed to clarify the open questions raised by possible consequences of a lack of an IgA response to SARS-CoV-2. |
topic |
IgA secretory IgA SARS-Cov-2 selective IgA deficiency infectivity |
url |
https://www.frontiersin.org/articles/10.3389/fcimb.2021.655896/full |
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